773-82-0Relevant articles and documents
Synthesis and Characterization of Bidentate (P^N)Gold(III) Fluoride Complexes: Reactivity Platforms for Reductive Elimination Studies
Genoux, Alexandre,Biedrzycki, Micha?,Merino, Estíbaliz,Rivera-Chao, Eva,Linden, Anthony,Nevado, Cristina
supporting information, p. 4164 - 4168 (2020/12/23)
A new family of cationic, bidentate (P^N)gold(III) fluoride complexes has been prepared and a detailed characterization of the gold-fluoride bond has been carried out. Our results correlate with the observed reactivity of the fluoro ligand, which undergoes facile exchange with both cyano and acetylene nucleophiles. The resulting (P^N)arylgold(III)C(sp) complexes have enabled the first study of reductive elimination on (P^N)gold(III) systems, which demonstrated that C(sp2)?C(sp) bond formation occurs at higher rates than those reported for analogous phosphine-based monodentate systems.
Mechanistic Insights into C(sp2)?C(sp)N Reductive Elimination from Gold(III) Cyanide Complexes
Genoux, Alexandre,González, Jorge A.,Merino, Estíbaliz,Nevado, Cristina
, p. 17881 - 17886 (2020/08/19)
A new family of phosphine-ligated dicyanoarylgold(III) complexes has been prepared and their reactivity towards reductive elimination has been studied in detail. Both, a highly positive entropy of activation and a primary 12/13C KIE suggest a late concerted transition state while Hammett analysis and DFT calculations indicate that the process is asynchronous. As a result, a distinct mechanism involving an asynchronous concerted reductive elimination for the overall C(sp2)?C(sp)N bond forming reaction is characterized herein, for the first time, complementing previous studies reported for C(sp3)?C(sp3), C(sp2)?C(sp2), and C(sp3)?C(sp2) bond formation processes taking place on gold(III) species.
Preparation method of pentafluorobenzonitrile
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Paragraph 0042; 0043; 0044; 0045; 0046; 0047; 0048; 0049, (2017/07/19)
The invention discloses a preparation method of pentafluorobenzonitrile. The method comprises the following steps: (1) introducing oxygen gas and ammonia gas into a mixed system of 2,6-dichloro-3-fluoroacetophenone, copper salt, a phase transfer catalyst and a solvent A to perform reaction to obtain 2,6-dichloro-3-fluorobenzonitrile; (2) perchlorinating the 2,6-dichloro-3-fluorobenzonitrile under the action of a catalyst to obtain 2,3,4,6-tetrachloro-5- fluorobenzonitrile; (3) adding the 2,3,4,6-tetrachloro-5-fluorobenzonitrile, KF and the phase transfer catalyst into a solvent B, and performing fluoridation to obtain the pentafluorobenzonitrile. The 2,6-dichloro-3-fluoroacetophenone used in the preparation method is a by-product in producing 2,4-dichloro-5-fluoroacetophenone, and the total yield of a single cycle can reach 83%; the raw materials are cheap and easy to obtain, the cost is reduced, and the environment is protected; and the synthetic process is simple, the operation is convenient, the yield is relatively high, the purity is good, and the pentafluorobenzonitrile is suitable for industrial production.