1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate
• CAS No.: 1093988-39-6
• Molecular Formula: C₁₇H₂₅N₃O₅
• Molecular Weight: 351.403
• Mol file: 1093988-39-6.mol

Synonyms:1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate

Chemical Property of 1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate

There total 7 articles about 1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl (2R)-2-[({4-[(methyloxy)carbonyl]phenyl}oxy)methyl]-4-morpholinecarboxylate (1093988-38-5) → 1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate (1093988-39-6)

Guidance literature:

With hydrazine; In ethanol; for 4h; Reflux;

Reference yield:

N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide (929278-88-6) → 1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate (1093988-39-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; hexane; mineral oil / 1 h / 0 - 20 °C

1.2: 20 °C

1.3: 0 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 144 h / 760.05 Torr

3.1: naphthalene; sodium / tetrahydrofuran / 0.08 h / 0 °C

4.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.42 h / 120 °C / microwave reactor

6.1: hydrazine / ethanol / 4 h / Reflux

With dmap; naphthalene; hydrogen; sodium; sodium hydride; potassium carbonate; triethylamine; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

(2R)-1-[(2-hydroxyethyl)amino]-3-[(phenylmethyl)oxy]-2-propanol (929278-86-4) → 1,1-dimethylethyl (2R)-2-({[4-(hydrazinocarbonyl)phenyl]oxy}methyl)-4-morpholinecarboxylate (1093988-39-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; hexane; mineral oil / 1 h / 0 - 20 °C

2.2: 20 °C

2.3: 0 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 144 h / 760.05 Torr

4.1: naphthalene; sodium / tetrahydrofuran / 0.08 h / 0 °C

5.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.42 h / 120 °C / microwave reactor

7.1: hydrazine / ethanol / 4 h / Reflux

With dmap; naphthalene; hydrogen; sodium; sodium hydride; potassium carbonate; triethylamine; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

tert-butyl (2R)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)morpholine-4-carboxylate

(R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

(2R)-1-[(2-hydroxyethyl)amino]-3-[(phenylmethyl)oxy]-2-propanol

N-(2-hydroxyethyl)-N-{(2R)-2-hydroxy-3-[(phenylmethyl)oxy]propyl}-4-methylbenzenesulfonamide