[3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Base Information

Chemical Name:[3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone
CAS No.:1574110-72-7
Molecular Formula:C₂₄H₂₁Cl₂F₃N₂O₂
Molecular Weight:497.344
Hs Code.:

Synonyms:[3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

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Chemical Property of [3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

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Technology Process of [3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

There total 6 articles about [3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1574118-42-5
(3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl)(morpholino)methanone

: 766-80-3
1-bromomethyl-3-chlorobenzene

: 1574110-72-7
[3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃;

Reference yield:

: 37629-52-0
(E)-1-(4-chlorophenyl)-2-nitropropene

: 1574110-72-7
[3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 1,5,7-triazabicyclo[4.4.0]dec-5-ene polystyrene / tetrahydrofuran; isopropyl alcohol / 20 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 110 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

4: ferrous(II) sulfate heptahydrate; dihydrogen peroxide / dimethyl sulfoxide; water / 0.13 h / 20 °C / Cooling with ether-dry ice

5: potassium carbonate / acetonitrile / 80 °C

With ferrous(II) sulfate heptahydrate; 1-hydroxy-7-aza-benzotriazole; water; dihydrogen peroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;

Reference yield:

: 126760-74-5
ethyl 3-(4-chlorophenyl)-4-methyl-1H-pyrrole-2-carboxylate

: 1574110-72-7
[3-(4-chlorophenyl)-1-[(3-chlorophenyl)-methyl]-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 110 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3: ferrous(II) sulfate heptahydrate; dihydrogen peroxide / dimethyl sulfoxide; water / 0.13 h / 20 °C / Cooling with ether-dry ice

4: potassium carbonate / acetonitrile / 80 °C

With ferrous(II) sulfate heptahydrate; 1-hydroxy-7-aza-benzotriazole; water; dihydrogen peroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;