2-(4,5-dihydro-1H-imidazol-2-yl)quinoline

Base Information

Chemical Name:2-(4,5-dihydro-1H-imidazol-2-yl)quinoline
CAS No.:187173-05-3
Molecular Formula:C₁₂H₁₁N₃
Molecular Weight:197.239
Hs Code.:
DSSTox Substance ID:DTXSID001272339
Nikkaji Number:J786.453A
Wikidata:Q27164701
Pharos Ligand ID:9VXYY6R2H877
ChEMBL ID:CHEMBL13698
Mol file:187173-05-3.mol

Synonyms:BU 224;BU-224;BU224

Suppliers and Price of 2-(4,5-dihydro-1H-imidazol-2-yl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
BU 224 Hydrochloride
10mg
$ 400.00

Tocris
BU224hydrochloride
50
$ 562.00

Tocris
BU224hydrochloride
10
$ 133.00

American Custom Chemicals Corporation
2-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)QUINOLINE 95.00%
50MG
$ 1041.76

American Custom Chemicals Corporation
2-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)QUINOLINE 95.00%
10MG
$ 660.95

Total 7 raw suppliers

Chemical Property of 2-(4,5-dihydro-1H-imidazol-2-yl)quinoline

Chemical Property:

Vapor Pressure:9.33E-06mmHg at 25°C
Boiling Point:372.9°Cat760mmHg
PKA:9.87±0.40(Predicted)
Flash Point:179.3°C
PSA：37.28000
Density:g/cm³
LogP:2.15100
Storage Temp.:Desiccate at RT
Solubility.:ethanol: 1.2 mg/mL
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:197.095297364
Heavy Atom Count:15
Complexity:262

Purity/Quality:

98%Min ^*data from raw suppliers

BU 224 Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN=C(N1)C2=NC3=CC=CC=C3C=C2
Uses BU224 is one of the two most widely studied I2 receptor ligands and have antinociceptive and antidepressant-?like activities in rodents.

Technology Process of 2-(4,5-dihydro-1H-imidazol-2-yl)quinoline

There total 4 articles about 2-(4,5-dihydro-1H-imidazol-2-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 5470-96-2
quinoline 2-carbaldehyde

: 107-15-3,85404-18-8
ethylenediamine

: 187173-05-3
2-(2-imidazolin-2-yl)quinoline

Guidance literature:: quinoline 2-carbaldehyde; ethylenediamine; In dichloromethane; at 20 ℃; for 1h;

With N-Bromosuccinimide; In dichloromethane; at 0 ℃; for 8h;
DOI:10.1016/j.tetlet.2021.153627

Reference yield:

: C₁₂H₁₃N₃

: 187173-05-3
2-(2-imidazolin-2-yl)quinoline

Guidance literature:: With N-Bromosuccinimide; In water; at 65 - 70 ℃; for 0.3h; Ultrasound irradiation;
DOI:10.1016/j.bmcl.2008.03.001

Reference yield:

: 5470-96-2
quinoline 2-carbaldehyde

: 187173-05-3
2-(2-imidazolin-2-yl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: water / 0.03 h / Ultrasound irradiation

2: N-Bromosuccinimide / water / 0.3 h / 65 - 70 °C / Ultrasound irradiation

With N-Bromosuccinimide; In water;
DOI:10.1016/j.bmcl.2008.03.001