3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine

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Chemical Name:3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine
CAS No.:220481-72-1
Molecular Formula:C₆₈H₁₁₃N₁₃O₁₅
Molecular Weight:1352.72
Hs Code.:

3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine

Synonyms:3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine

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Chemical Property of 3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine

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Technology Process of 3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine

There total 2 articles about 3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 220481-70-9
5-<4,8-bis(tert-butyloxycarbonyl)-11-<4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl>-1,4,8,11-tetraazacyclotetradecanyl> pentanoic acid

: 220481-72-1
3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine

Guidance literature:: With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 8h; Ambient temperature;
DOI:10.1021/jm980358u

Reference yield:

: 623-24-5
1,4-bis(bromomethyl)benzene

: 220481-72-1
3'-azido-3'-deoxy-5'-O-<5-<4,8-bis(tert-butyloxycarbonyl)-11-(4-<<4,8,11-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecanyl>methyl>benzyl)-1,4,8,11-tetraazacyclotetradecanyl>pentanoyl>thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) K₂CO₃, 2.) 5 N aq. NaOH, Triton B / 1.) CH₃CN, reflux, 8 h, 2.) THF, RT, 4 h

2: 35 percent / DMAP, NEt₃, benzotriazol-1-yloxy-tris(pyrrolidino) phosphonium hexafluorophosphate / CH₂Cl₂; dimethylformamide / 8 h / Ambient temperature

With dmap; sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-benzyl-trimethylammonium hydroxide; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980358u