methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate

Base Information

• Chemical Name: methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate
• CAS No.: 1007859-56-4
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.402
• Mol file: 1007859-56-4.mol

Synonyms:methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate

Chemical Property of methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate

There total 1 articles about methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

4-methoxycarbonylbenzyltriphenylphosphonium bromide (1253-46-9) + N-[(4-formylphenyl)methyl]prop-2-enyloxycarboxamide (1007859-13-3) → methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate (1007859-56-4)

Guidance literature:

4-methoxycarbonylbenzyltriphenylphosphonium bromide; With 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; dichloromethane; for 0.0833333h;

N-[(4-formylphenyl)methyl]prop-2-enyloxycarboxamide; In tetrahydrofuran; dichloromethane; for 10h; Heating;

DOI:10.1021/ja0394434

Reference yield: 91.0%

methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate (1007859-56-4) → 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid (1007859-60-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 12h; Heating;

DOI:10.1021/ja0394434

Reference yield:

methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate (1007859-56-4) → 3-[4-{(E)-2-[4-(allyloxycarbonyl)aminomethylphenyl]vinyl}benzocarbonyl]amino-1-propanol

Guidance literature:

Multi-step reaction with 2 steps

1.1: 91 percent / aq. LiOH / tetrahydrofuran / 12 h / Heating

2.1: HOBT; HBTU; Et₂NH / dimethylformamide / 0.25 h / 20 °C

2.2: 89 percent / dimethylformamide / 10 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja0394434

upstream raw materials:

4-methoxycarbonylbenzyltriphenylphosphonium bromide

N-[(4-formylphenyl)methyl]prop-2-enyloxycarboxamide

Downstream raw materials:

4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid