4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid

Base Information

• Chemical Name: 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid
• CAS No.: 1007859-60-0
• Molecular Formula: C₂₀H₁₉NO₄
• Molecular Weight: 337.375
• Mol file: 1007859-60-0.mol

Synonyms:4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid

Chemical Property of 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid

There total 1 articles about 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate (1007859-56-4) → 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid (1007859-60-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 12h; Heating;

DOI:10.1021/ja0394434

Reference yield: 89.0%

propan-1-ol-3-amine (156-87-6) + 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid (1007859-60-0) → 3-[4-{(E)-2-[4-(allyloxycarbonyl)aminomethylphenyl]vinyl}benzocarbonyl]amino-1-propanol

Guidance literature:

4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

propan-1-ol-3-amine; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

DOI:10.1021/ja0394434

Reference yield:

4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoic acid (1007859-60-0) → 3-[4-{(E)-2-[4-(allyloxycarbonyl)aminomethylphenyl]vinyl}benzocarbonyl]-3-(aminopropyl)-1-O-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:

Multi-step reaction with 2 steps

1.1: HOBT; HBTU; Et₂NH / dimethylformamide / 0.25 h / 20 °C

1.2: 89 percent / dimethylformamide / 10 h / 20 °C

2.1: 50 percent / diisopropylammonium tetrazolide / acetonitrile / 6 h

With N,N-diisopropylamine tetrazolide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja0394434

upstream raw materials:

methyl 4-{(E)-2-[4-({[(allyloxy)carbonyl]amino}methyl)phenyl]vinyl}benzoate