trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid

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Chemical Name:trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid
CAS No.:1072907-25-5
Molecular Formula:C₃₆H₄₁F₉N₄O₃S
Molecular Weight:780.798
Hs Code.:

trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid

Synonyms:trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid

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Chemical Property of trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid

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Technology Process of trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid

There total 3 articles about trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072907-24-4
C₃₈H₄₅F₉N₄O₃S

: 1072907-25-5
trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid

Guidance literature:: C₃₈H₄₅F₉N₄O₃S; With sodium hydroxide; In ethanol; water; at 50 ℃; for 3.5h; Cooling with ice;

With hydrogenchloride; In ethanol; water; pH=5.4;

Reference yield:

: 225920-05-8
(S)-3,5-bis(trifluoromethyl)-1-phenylethanol

: 1072907-25-5
trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; 1,2-dibromo-1,1,2,2-tetrachloroethane / toluene / 1.17 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: 5 h / -30 - 15 °C

3.1: sodium hydroxide / ethanol; water / 3.5 h / 50 °C / Cooling with ice

3.2: pH 5.4

With 1,2-dibromo-1,1,2,2-tetrachloroethane; sodium hydride; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; water; toluene; mineral oil;

Reference yield:

: 1351520-15-4
(R)-1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane

: 1072907-25-5
trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 5 h / -30 - 15 °C

2.1: sodium hydroxide / ethanol; water / 3.5 h / 50 °C / Cooling with ice

2.2: pH 5.4

With sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; water; mineral oil;