trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

Base Information

Chemical Name:trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester
CAS No.:1351520-18-7
Molecular Formula:C₄₃H₄₇F₉N₄O₅S
Molecular Weight:902.922
Hs Code.:

trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

Synonyms:trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

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Chemical Property of trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

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Technology Process of trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

There total 5 articles about trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351520-16-5
trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

: 1351520-18-7
trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

: 1370726-03-6
trans-{4-[({2-[({(R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

Guidance literature:: With dihydrogen peroxide; tantalum pentachloride; In water; isopropyl alcohol; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 225920-05-8
(S)-3,5-bis(trifluoromethyl)-1-phenylethanol

: 1351520-18-7
trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

: 1370726-03-6
trans-{4-[({2-[({(R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; 1,2-dibromo-1,1,2,2-tetrachloroethane / toluene / 1.17 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: 5 h / -30 - 15 °C

3.1: sodium hydroxide / ethanol; water / 3.5 h / 50 °C / Cooling with ice

3.2: pH 5.4

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere; Cooling with ice

5.1: dihydrogen peroxide; tantalum pentachloride / isopropyl alcohol; water / 5 h / 20 °C / Inert atmosphere

With dmap; 1,2-dibromo-1,1,2,2-tetrachloroethane; dihydrogen peroxide; tantalum pentachloride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; isopropyl alcohol; toluene; mineral oil;

Reference yield:

: 1351520-15-4
(R)-1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane

: 1351520-18-7
trans-{4-[({2-[({(S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

: 1370726-03-6
trans-{4-[({2-[({(R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 5 h / -30 - 15 °C

2.1: sodium hydroxide / ethanol; water / 3.5 h / 50 °C / Cooling with ice

2.2: pH 5.4

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere; Cooling with ice

4.1: dihydrogen peroxide; tantalum pentachloride / isopropyl alcohol; water / 5 h / 20 °C / Inert atmosphere

With dmap; dihydrogen peroxide; tantalum pentachloride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; isopropyl alcohol; mineral oil;