Technology Process of C41H39NO4
There total 6 articles about C41H39NO4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
water; toluene;
at 100 ℃;
for 17h;
Inert atmosphere;
DOI:10.1021/ol5009087
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: p-toluenesulfonic acid monohydrate / water; acetone / 144 h
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran; cyclohexane / 3 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 - 20 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 60 h / 5 - 20 °C
5.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / 17 h / 100 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; p-toluenesulfonic acid monohydrate; sodium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; cyclohexane; water; acetone; toluene;
5.1: |Suzuki Coupling;
DOI:10.1021/ol5009087
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.75 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 - 20 °C / Inert atmosphere
2.1: p-toluenesulfonic acid monohydrate / water; acetone / 144 h
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; cyclohexane / 3 h / -78 °C / Inert atmosphere
4.2: 2 h / -78 - 20 °C / Inert atmosphere
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 60 h / 5 - 20 °C
6.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / 17 h / 100 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; p-toluenesulfonic acid monohydrate; sodium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; cyclohexane; water; acetone; toluene;
6.1: |Suzuki Coupling;
DOI:10.1021/ol5009087