4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one

Base Information

Chemical Name:4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one
CAS No.:1332329-80-2
Molecular Formula:C₂₅H₂₈N₂O₇S
Molecular Weight:500.573
Hs Code.:

Synonyms:4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one

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Chemical Property of 4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one

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Technology Process of 4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one

There total 7 articles about 4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1332329-77-7
4-(mesyloxymethyl)-6-phenyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one

: 105-53-3
diethyl malonate

: 1332329-80-2
4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one

Guidance literature:: diethyl malonate; With sodium hydride; In acetonitrile; for 0.166667h;

4-(mesyloxymethyl)-6-phenyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one; In acetonitrile; at 20 ℃; for 3.88333h;
DOI:10.1016/j.tet.2011.06.089

Reference yield: 80.0%

: 1332329-78-8
4-(chloromethyl)-6-phenyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one

: 105-53-3
diethyl malonate

: 1332329-80-2
4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one

Guidance literature:: diethyl malonate; With sodium hydride; In acetonitrile; for 0.166667h;

4-(chloromethyl)-6-phenyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one; In acetonitrile; at 20 ℃; for 4.63333h;
DOI:10.1016/j.tet.2011.06.089

Reference yield:

: 31378-03-7
1-phenyl-2-tosylethanone

: 1332329-80-2
4-[di(ethoxycarbonyl)methyl]-7-phenyl-6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / acetonitrile / Cooling with ice

1.2: 8.27 h / 20 °C

2.1: toluene-4-sulfonic acid / acetonitrile / 20 h / Reflux

3.1: water; potassium hydroxide / ethanol / 2 h / 20 °C

4.1: dmap / dichloromethane / 0.82 h / 0 °C / Reflux

5.1: sodium hydride / acetonitrile / 0.17 h

5.2: 3.88 h / 20 °C

With dmap; water; sodium hydride; toluene-4-sulfonic acid; potassium hydroxide; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2011.06.089