2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol

Base Information

• Chemical Name: 2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol
• CAS No.: 1333501-34-0
• Molecular Formula: C₁₉H₃₁NO₂
• Molecular Weight: 305.461
• Mol file: 1333501-34-0.mol

Synonyms:2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol

Chemical Property of 2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol

There total 1 articles about 2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

tempol (2226-96-2) + 4-bromo-isobutylbenzene (57181-82-5) → 2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol (1333501-34-0)

Guidance literature:

With copper(II) trifluoroacetate; copper; 4,4'-di-tert-butyl-2,2'-bipyridine; In benzene; at 75 ℃; for 72h; Inert atmosphere;

DOI:10.1002/chem.201100543

Reference yield: 92.0%

2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol (1333501-34-0) → 2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-one (1333501-35-1)

Guidance literature:

With oxalyl dichloride; triethylamine; In dichloromethane; dimethyl sulfoxide; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201100543

Reference yield:

2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ol (1333501-34-0) → 2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ylamine (1333501-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / -78 - 20 °C / Inert atmosphere

2: ammonium acetate; sodium cyanoborohydride / methanol / 20 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; ammonium acetate; sodium cyanoborohydride; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/chem.201100543

upstream raw materials:

tempol

4-bromo-isobutylbenzene

Downstream raw materials:

2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-one

2,2,6,6-tetramethyl-1-(2-methyl-1-phenylpropoxy)piperidine-4-ylamine

C₄₆H₆₀N₄O₇S₂