3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Base Information

Chemical Name:3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid
CAS No.:1445878-75-0
Molecular Formula:C₂₈H₂₉N₅O₇S
Molecular Weight:579.634
Hs Code.:

Synonyms:3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Chemical Property of 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Technology Process of 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

There total 9 articles about 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445880-04-5
3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445878-75-0
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 125 ℃; for 0.416667h; Microwave irradiation;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445878-75-0
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C

4: acetic acid / 24 h / 20 °C

5: water; sodium hydroxide / methanol / 4 h / 20 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.42 h / 125 °C / Microwave irradiation

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1445879-89-9
7-bromo-4-chloro-N-cyclopropyl-3-quinolinesulfonamide

: 1445878-75-0
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 24 h / 20 °C

2: water; sodium hydroxide / methanol / 4 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.42 h / 125 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; water;