3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Base Information

• Chemical Name: 3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid
• CAS No.: 1445880-04-5
• Molecular Formula: C₂₂H₂₂BrN₃O₅S
• Molecular Weight: 520.404
• Mol file: 1445880-04-5.mol

Synonyms:3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Chemical Property of 3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

There total 8 articles about 3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopropyl 3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoate → 3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid (1445880-04-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 4h;

Reference yield:

4-hydroxy-7-bromoquinoline (82121-06-0) → 3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid (1445880-04-5)

Guidance literature:

Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C

4: acetic acid / 24 h / 20 °C

5: water; sodium hydroxide / methanol / 4 h / 20 °C

With chlorosulfonic acid; water; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In methanol; dichloromethane;

Reference yield:

7-bromo-4-chloro-N-cyclopropyl-3-quinolinesulfonamide (1445879-89-9) → 3-((7-bromo-3-(N-cyclopropylsulfamoyl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid (1445880-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 24 h / 20 °C

2: water; sodium hydroxide / methanol / 4 h / 20 °C

With water; acetic acid; sodium hydroxide; In methanol;

upstream raw materials:

7-bromo-4-chloro-N-cyclopropyl-3-quinolinesulfonamide

7-bromo-4-hydroxy-3-quinolinesulfonyl chloride

4-hydroxy-7-bromoquinoline

methyl 3-[(1-methylethyl)oxy]-5-nitrobenzoate

Downstream raw materials:

3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid