(E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride

Base Information

Chemical Name:(E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride
CAS No.:84050-32-8
Molecular Formula:C₂₅H₂₉N₅O₄*ClH
Molecular Weight:499.997
Hs Code.:

Synonyms:(E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride

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Chemical Property of (E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride

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Technology Process of (E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride

There total 3 articles about (E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 70842-56-7
1-[3-(2-ethoxy-phenyl)-acryloyl]-piperazine

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 84050-32-8
(E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride

Guidance literature:: In i-Amyl alcohol; for 3h; Heating;
DOI:10.1021/jm00357a016

Reference yield:

: 69038-81-9
2-ethoxy cinnamic acid

: 84050-32-8
(E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / benzene / 3 h / Heating

2: 47 percent HBr / tetrahydrofuran; ethanol / 2 h / Heating

3: 90 percent / 3-methyl-butan-1-ol / 3 h / Heating

With thionyl chloride; hydrogen bromide; In tetrahydrofuran; ethanol; i-Amyl alcohol; benzene;
DOI:10.1021/jm00357a016

Reference yield:

: (E)-3-(2-Ethoxy-phenyl)-acryloyl chloride

: 84050-32-8
(E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent HBr / tetrahydrofuran; ethanol / 2 h / Heating

2: 90 percent / 3-methyl-butan-1-ol / 3 h / Heating

With hydrogen bromide; In tetrahydrofuran; ethanol; i-Amyl alcohol;
DOI:10.1021/jm00357a016