3-(2-Ethoxyphenyl)-2-propenoic acid

Base Information

• Chemical Name: 3-(2-Ethoxyphenyl)-2-propenoic acid
• CAS No.: 69038-81-9
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID101294809
• Mol file: 69038-81-9.mol

Synonyms:DTXSID101294809;3-(2-Ethoxyphenyl)-2-propenoic acid;AKOS030239962;FT-0612212;D85915

Chemical Property of 3-(2-Ethoxyphenyl)-2-propenoic acid

Chemical Property:

• Appearance/Colour: WHITE TO OFF-WHITE SOLID, POWDER OR CRYSTALS
• Vapor Pressure: 4.18E-05mmHg at 25°C
• Melting Point: 134-138 °C(lit.)
• Refractive Index: 1.579
• Boiling Point: 337.161 °C at 760 mmHg
• Flash Point: 131.71 °C
• PSA: 46.53000
• Density: 1.161 g/cm³
• LogP: 2.18310
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 192.078644241
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

97% ^*data from raw suppliers

2-EthoxycinnamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1C=CC(=O)O

Technology Process of 3-(2-Ethoxyphenyl)-2-propenoic acid

There total 4 articles about 3-(2-Ethoxyphenyl)-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid (141-82-2) + 2-ethoxylbenzaldehyde (613-69-4) → 2-ethoxy cinnamic acid (69038-81-9)

Guidance literature:

malonic acid; 2-ethoxylbenzaldehyde; With piperidine; pyridine; Reflux;

With hydrogenchloride; In water; at 25 ℃;

DOI:10.3390/molecules14104166

Reference yield:

malonic acid (141-82-2) + 2-ethoxylbenzaldehyde (613-69-4) + acetic acid (64-19-7,77671-22-8) → 2-ethoxy cinnamic acid (69038-81-9)

Guidance literature:

at 140 - 150 ℃;

Reference yield:

pyridine (110-86-1) + malonic acid (141-82-2) + 2-ethoxylbenzaldehyde (613-69-4) → 2-ethoxy cinnamic acid (69038-81-9)

Guidance literature:

upstream raw materials:

pyridine

malonic acid

2-ethoxylbenzaldehyde

acetic acid

Downstream raw materials:

8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6-(5H)-one

1-[3-(2-ethoxy-phenyl)-acryloyl]-piperazine

(E)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-(2-ethoxy-phenyl)-propenone; hydrochloride

5-(2-ethoxyphenyl)-4,5-dihydro-[1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline