(S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate

Base Information

Chemical Name:(S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate
CAS No.:1013917-12-8
Molecular Formula:C₂₁H₂₅N₃O₅
Molecular Weight:399.447
Hs Code.:

Synonyms:(S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate

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Chemical Property of (S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate

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Technology Process of (S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate

There total 5 articles about (S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 10065-72-2
L-Alanine methyl ester

: 1161-13-3
N-Cbz-L-Phe

: 1013917-12-8
(S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate

Guidance literature:: N-Cbz-L-Phe; With diphenyl-phosphinic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h;

L-Alanine methyl ester; In tetrahydrofuran; for 0.5h; Further stages.; Heating;
DOI:10.1016/j.tetlet.2007.12.060

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1013917-12-8
(S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.25 h / 0 °C

2.1: sodium azide / tetrahydrofuran; dimethyl sulfoxide / 0.33 h / 0 °C

3.1: tetrahydrofuran; dimethyl sulfoxide / 0.17 h / Sonication

4.1: zinc

4.2: 0.25 h / Sonication

With sodium azide; zinc; In tetrahydrofuran; dimethyl sulfoxide; 3.1: Curtius rearrangement;
DOI:10.2174/092986611797200922

Reference yield:

: 62067-14-5
(S)-benzyl 1-azido-1-oxo-3-phenylpropan-2-ylcarbamate

: 1013917-12-8
(S)-methyl 2-(3-((S)-1-(benzyloxycarbonylamino)-2-phenylethyl)ureido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran; dimethyl sulfoxide / 0.17 h / Sonication

2.1: zinc

2.2: 0.25 h / Sonication

With zinc; In tetrahydrofuran; dimethyl sulfoxide; 1.1: Curtius rearrangement;
DOI:10.2174/092986611797200922