C₁₀H₉ClO₃

Base Information

• Chemical Name: C₁₀H₉ClO₃
• CAS No.: 219975-11-8
• Molecular Formula: C₁₀H₉ClO₃
• Molecular Weight: 212.633
• Mol file: 219975-11-8.mol

Synonyms:C₁₀H₉ClO₃

Chemical Property of C₁₀H₉ClO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₉ClO₃

There total 1 articles about C₁₀H₉ClO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-chloro-benzeneacetic acid (2444-36-2) + cycl-isopropylidene malonate (2033-24-1) → C10H9ClO3 (219975-11-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol400926p

Reference yield:

C10H9ClO3 (219975-11-8) → C26H32ClNO6S

Guidance literature:

Multi-step reaction with 2 steps

1: 5 h / Reflux; Inert atmosphere

2: C₃₅H₃₃NOSi; water; lithium acetate / neat (no solvent) / 24 h / 20 °C

With C₃₅H₃₃NOSi; lithium acetate; water; In neat (no solvent);

DOI:10.1021/ol400926p

Reference yield:

C10H9ClO3 (219975-11-8) → (1R,5S,8R)-tert-butyl 8-(2-chlorophenyl)-7-hydroxy-2-(4-methylphenylsulfonyl)-2-azabicyclo[3.3.1]non-6-ene-6-carboxylate (1431726-61-2) + (1S,5R,8S)-tert-butyl 8-(2-chlorophenyl)-7-hydroxy-2-(4-methylphenylsulfonyl)-2-azabicyclo[3.3.1]non-6-ene-6-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: 5 h / Reflux; Inert atmosphere

2: C₃₅H₃₃NOSi; water; lithium acetate / neat (no solvent) / 24 h / 20 °C

3: lithium hydroxide monohydrate; water / isopropyl alcohol / 24 h / Inert atmosphere

With lithium hydroxide monohydrate; C₃₅H₃₃NOSi; lithium acetate; water; In isopropyl alcohol;

DOI:10.1021/ol400926p

upstream raw materials:

2'-chloro-benzeneacetic acid

cycl-isopropylidene malonate

Downstream raw materials:

(1R,5S,8R)-tert-butyl 8-(2-chlorophenyl)-7-hydroxy-2-(4-methylphenylsulfonyl)-2-azabicyclo[3.3.1]non-6-ene-6-carboxylate

tert-butyl 4-(2-chlorophenyl)-3-oxobutanoate