2444-36-2

Basic information

• Product Name: 2-Chlorophenylacetic acid
• Synonyms: RARECHEM AL BO 0111;O-CHLOROPHENYLACETIC ACID;OCPA;chlorophenylaceticacid;2-CHLOROPHENYLACETIC ACID;LABOTEST-BB LT00452739;2-ChlorophenylaceticAcid,>99%;2-Chlorophenylacetic acid, 98.5+%
• CAS NO: 2444-36-2
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• EINECS: 219-482-0
• Product Categories: Phenylacetic acid series;Acids and Derivatives;Aromatic Phenylacetic Acids and Derivatives;Organic acids;C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 2444-36-2.mol
• Article Data: 28

Chemical Properties

• Melting Point: 92-95 °C(lit.)
• Boiling Point: 145°C 5mm
• Flash Point: 145°C/5mm
• Appearance: White to light yellow/Powder
• Density: 1.2315 (rough estimate)
• Vapor Pressure: 0.000751mmHg at 25°C
• Refractive Index: 1.5660 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 4.07(at 25℃)
• BRN: 1101523
• CAS DataBase Reference: 2-Chlorophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chlorophenylacetic acid(2444-36-2)
• EPA Substance Registry System: 2-Chlorophenylacetic acid(2444-36-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37-36
• WGK Germany: 3
• F: 13
• Hazardous Substances Data: 2444-36-2(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO LIGHT YELLOW POWDER

Uses

2-Chlorophenylacetic acid has been used in the synthesis of phenylacetoxy cellulosics and its halogenated derivatives.

General Description

Acidity constant (pKa) of 2-chlorophenylacetic acid in water has been evaluated.

InChI:InChI=1/C8H7ClO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)/p-1

Synthetic route

2-(2-chloro-phenyl)-1-pyrrolidin-1-yl-ethanone (512787-31-4) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With hydrogenchloride In 1,4-dioxane for 38h; Heating;	98%

2-chlorophenylacetic acid ethyl ester (40061-54-9) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With water; sodium hydroxide In 1,4-dioxane at 60℃; for 2h; pH=10 - 14;	94%

1-chloro-2-(chloromethyl)benzene (611-19-8) + butan-1-ol (71-36-3) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
Stage #1: butan-1-ol With cobalt(II) acetate; cobalt(II) nitrate at 40℃; under 3750.38 Torr; for 2h; Autoclave; Stage #2: 1-chloro-2-(chloromethyl)benzene With sodium hydroxide In water at 40℃; under 2250.23 Torr; for 12h; Concentration; Pressure; Temperature; Autoclave;	93.7%

carbon dioxide (124-38-9) + 1-chloro-2-(chloromethyl)benzene (611-19-8) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; manganese; palladium diacetate; magnesium chloride In N,N-dimethyl-formamide under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique;	92%
With (1,2-dimethoxyethane)dichloronickel(II); C15H27P*(x)BF4*H(1+); magnesium chloride; zinc In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; Schlenk technique;	62%
With samarium; chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; under 760.051 Torr; for 2h; Electrochemical reaction; Cooling with ice;	42%
Stage #1: 1-chloro-2-(chloromethyl)benzene With magnesium; lithium chloride; zinc(II) chloride In tetrahydrofuran at 25℃; for 1h; Stage #2: carbon dioxide In tetrahydrofuran at 50℃; for 12h;	272 mg

C15H14ClNO4S → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With sodium tetrahydroborate; trifluoroacetic acid In dichloromethane at 15 - 25℃;	92%

carbon monoxide (201230-82-2) + 1-bromomethyl-2-chlorobenzene (611-17-6) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Autoclave;	92%
With palladium hydroxide, 20 wt% on carbon; tetrabutylammomium bromide; water In tetrahydrofuran at 110℃; under 7500.75 Torr; for 4h; Sealed tube; Autoclave;	70%

carbon monoxide (201230-82-2) + 1-chloro-2-(chloromethyl)benzene (611-19-8) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
Stage #1: carbon monoxide With C28H22CoN4O6 In butan-1-ol at 60℃; under 760.051 Torr; for 2h; Glovebox; High pressure; Green chemistry; Stage #2: 1-chloro-2-(chloromethyl)benzene With tetra-(n-butyl)ammonium iodide; sodium hydroxide In butan-1-ol at 60℃; under 760.051 Torr; for 22h; Glovebox; High pressure; Green chemistry; regioselective reaction;	88%
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Reagent/catalyst; Autoclave;	88%
With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride; sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; under 11251.1 Torr; for 20h; Autoclave; regioselective reaction;	85%
With sodium hydroxide; cerium(III) chloride; cetyltrimethylammonim bromide; nickel cyanide In toluene at 85 - 95℃; under 1 Torr; for 6.5h;	76%
With water; palladium diacetate at 110℃; under 37503.8 Torr; for 4h; Ionic liquid;	96 %Chromat.

carbon dioxide (124-38-9) + 2-(2-chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1365565-86-1) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With potassium ethoxide In 1,4-dioxane at 100℃; for 24h;	57%

formic acid (64-18-6) + 1-chloro-2-(chloromethyl)benzene (611-19-8) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium diacetate In N,N-dimethyl-formamide at 115℃; for 24h; Inert atmosphere;	50%

1-Phenylethanol (98-85-1, 13323-81-4) + 2-(2-chlorophenyl)acetyl chloride (51512-09-5) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
In diethyl ether	47%

carbon monoxide (201230-82-2) + 2-chlorobenzal bromide (67013-54-1) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With potassium hydroxide; dicobalt octacarbonyl; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 12h; Ambient temperature;	34%

1-methyl-4-nitrosobenzene (623-11-0) + 2-(2-chloro-phenyl)-3-hydroxy-3-propyl-hexanoic acid → 2'-chloro-benzeneacetic acid (2444-36-2)

2-(2-chlorophenyl)acetamide (10268-06-1) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With cis-nitrous acid
(saponification);

2-Chlorophenylacetonitrile (2856-63-5) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With sulfuric acid
With potassium hydroxide
With potassium hydroxide In ethanol for 24h; Heating;

4-(2-chlorobenzylidene)-2-phenyl-5-oxazolone (52900-69-3, 77435-90-6, 82301-55-1) + furan-2,3,5(4H)-trione pyridine (1:1) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
nachfolgend Oxydation mit Wasserstoffperoxyd;

2-acetoxy-2-(2-chlorophenyl)acetic acid (178437-75-7) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With Pd-BaSO4; tetralin

carbon dioxide (124-38-9) + (2-chloro-benzyl)-dimethyl-silane (51801-46-8) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
(i) Mg, (ii) /BRN= 1900390/; Multistep reaction;

2-(2-chlorophenyl)malonic acid (144616-14-8) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With AMDase; buffer solution at 15 - 35℃; Kinetics; ΔS(excit.), ΔH(excit.), ΔG(excit.);
With AMDase; buffer solution at 15℃; Rate constant;
With AMDase; buffer solution at 25℃; Rate constant;
With AMDase; buffer solution at 35℃; Rate constant;

[(E)-2-(2-Chloro-phenyl)-1-piperidin-1-yl-vinyl]-phosphonic acid diethyl ester → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With hydrogenchloride for 0.5h; Heating; Yield given;

2-phenyl-4-<2-chloro-benzyliden>-oxazolone-(5) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With sodium hydroxide Behandlung mit Wasserstoffperoxyd;

<2-chloro-phenyl>-thioacetic acid morpholide → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With sulfuric acid

etheric 2-chloro-benzyl magnesium chloride-solution → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
at 0℃; Einleiten von Kohlendioxid;

tetralin (119-64-2) + 2-acetoxy-2-(2-chlorophenyl)acetic acid (178437-75-7) + palladium → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
Hydrogenation;

2-(2-chloro-phenyl)-3-hydroxy-butyric acid + aqueous KOH-solution → 2'-chloro-benzeneacetic acid (2444-36-2) + acetaldehyde (75-07-0)

1-(2-chlorophenyl)-2-diazoethan-1-one (50878-84-7) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
With silver(l) oxide In 1,4-dioxane Rearrangement;

2-chloro-benzaldehyde (89-98-5) + (+-)-piperoin → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
Multi-step reaction with 3 steps 1: 99 percent / PPh3 / CH2Cl2 / 0.5 h / 0 °C 2: 96 percent / H2O / ethyl acetate / 8 h / 20 °C 3: 98 percent / aq. HCl / dioxane / 38 h / Heating View Scheme

1-chloro-2-(2,2-dibromovinyl)benzene (401514-40-7) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: 96 percent / H2O / ethyl acetate / 8 h / 20 °C 2: 98 percent / aq. HCl / dioxane / 38 h / Heating View Scheme

o-chlorobenzoyl chloride (609-65-4) → 2'-chloro-benzeneacetic acid (2444-36-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: diethyl ether / 0 °C 2: aq. Ag2O / dioxane View Scheme

methanol (67-56-1) + 2'-chloro-benzeneacetic acid (2444-36-2) → methyl (2-chlorophenyl)acetate (57486-68-7)

Conditions	Yield
With hydrogenchloride for 1h; Heating;	100%
With ammonium cerium(IV) nitrate at 20℃; for 12h;	99%
sulfuric acid for 16h; Heating / reflux;	97.5%

2'-chloro-benzeneacetic acid (2444-36-2) → 2-(2-chlorophenyl)acetyl chloride (51512-09-5)

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide In toluene	100%
With thionyl chloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane at 0 - 25℃; for 1h;	99%
With phosphorus pentachloride

2'-chloro-benzeneacetic acid (2444-36-2) + 4-bromo-2-(2-(dimethylamino)ethoxy)aniline (1072906-05-8) → N-(4-bromo-2-(2-(dimethylamino)ethoxy)phenyl)-2-(2-chlorophenyl)acetamide (1610875-39-2)

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;	100%

2'-chloro-benzeneacetic acid (2444-36-2) + 4-bromo-2-(2-methoxyethoxy)aniline (1219730-72-9) → N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide (1610875-66-5)

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;	100%

2'-chloro-benzeneacetic acid (2444-36-2) + N-cyclohexyl-cyclohexanamine (101-83-7) → C8H7ClO2*C12H23N

Conditions	Yield
In methanol at 20℃;	100%

2'-chloro-benzeneacetic acid (2444-36-2) + ethyl-3-benzylamino propionate (23583-21-3) → 3-{N-benzyl-N-[2-(2-chlorophenyl)acetyl]amino}propionic acid ethyl ester

Conditions	Yield
Stage #1: 2'-chloro-benzeneacetic acid; ethyl-3-benzylamino propionate With dmap In dichloromethane at 0℃; for 1h; Inert atmosphere; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane	99%

2'-chloro-benzeneacetic acid (2444-36-2) + 3-Formylchromone (17422-74-1) → (E)-2'-chloro-3-styrylchromone

Conditions	Yield
With pyridine; potassium tert-butylate for 12h; Heating;	98.4%

2'-chloro-benzeneacetic acid (2444-36-2) → 2-Chloro-5-nitrophenylacetic acid monohydrate

Conditions	Yield
With nitric acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid	98%

2'-chloro-benzeneacetic acid (2444-36-2) + ethanol (64-17-5) → 2-chlorophenylacetic acid ethyl ester (40061-54-9)

Conditions	Yield
With sulfuric acid Reflux;	97%
With toluene-4-sulfonic acid for 2h; Reflux;	94%
With hydrogenchloride Heating;	90%

2'-chloro-benzeneacetic acid (2444-36-2) + trimethyl orthoformate (149-73-5) → methyl (2-chlorophenyl)acetate (57486-68-7)

Conditions	Yield
With sulfuric acid In methanol; water at 20℃; for 4h;	97%

2'-chloro-benzeneacetic acid (2444-36-2) + Cyclohexanethiol (1569-69-3) → C14H17ClOS (1384863-33-5)

Conditions	Yield
With trifluoroacetic acid In acetonitrile at 60℃; for 5h;	96%

methanol (67-56-1) + 2'-chloro-benzeneacetic acid (2444-36-2) → methyl (2-hydroxyphenyl)acetate (22446-37-3)

Conditions	Yield
Stage #1: 2'-chloro-benzeneacetic acid With copper(l) chloride; sodium hydroxide In water at 250℃; for 8h; Autoclave; Stage #2: methanol With sulfuric acid In dichloromethane Temperature; Reflux;	95%

2'-chloro-benzeneacetic acid (2444-36-2) → 2-chloro-benzaldehyde (89-98-5)

Conditions	Yield
With dihydrogen peroxide In water; acetonitrile at 25℃; for 10h; UV-irradiation;	94%
With potassium 12-tungstocobaltate(III) In water; acetonitrile for 0.25h; Microwave irradiation;	92%
With 1H-imidazole; sodium periodate; {Mn(III)[5,10,15,20-tetrakis(4-H2N-Ph)porphyrin]}polystyrene In acetonitrile at 20℃; for 4h;	90%

2'-chloro-benzeneacetic acid (2444-36-2) + 5-(2,3-dihydro-1H-indol-5-yl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride → 5-{1-[(2-chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (1337531-39-1)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;	94%

2'-chloro-benzeneacetic acid (2444-36-2) + 3-methoxy-4-(4-methyloxazol-5-yl)aniline (1239719-44-8) → 2-(2-chlorophenyl)-N-(3-methoxy4-(4-methyloxazol-5-yl)phenyl)acetamide (1610874-83-3)

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 3.5h;	94%

2'-chloro-benzeneacetic acid (2444-36-2) + 4-bromo-2-[2-(morpholin-4-yl)ethoxy]aniline (1219728-38-7) → N-(4-bromo-2-(2-morpholinoethoxy)phenyl)-2-(2-chlorophenyl)acetamide (1610875-56-3)

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;	94%

2'-chloro-benzeneacetic acid (2444-36-2) → 2-Chlorobenzyl alcohol (17849-38-6)

Conditions	Yield
With sodium tetrahydroborate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; oxygen; caesium carbonate In dichloromethane at 40℃; for 40h; Irradiation;	94%

2'-chloro-benzeneacetic acid (2444-36-2) + copper(II) sulfate heptahydrate → 2-Hydroxyphenylacetic acid (614-75-5)

Conditions	Yield
With hydrogenchloride In water	93%

2'-chloro-benzeneacetic acid (2444-36-2) + N,0-dimethylhydroxylamine (1117-97-1) → 2-(2-chlorophenyl)-N-methoxy-N-methylacetamide (946402-82-0)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2h;	93%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; Inert atmosphere;

2'-chloro-benzeneacetic acid (2444-36-2) → 2-Chlorobenzonitrile (873-32-5)

Conditions	Yield
With oxygen; copper(II) trifluoroacetate; urea In dimethyl sulfoxide at 110℃; for 26h; Green chemistry;	93%
With iron(III) trifluoromethanesulfonate; sodium nitrite In dimethyl sulfoxide at 50℃; for 10h; Inert atmosphere; Sealed tube;	46%

2'-chloro-benzeneacetic acid (2444-36-2) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-(2-chlorophenyl)-4-phenylquinazoline (1283751-33-6)

Conditions	Yield
With ammonium acetate; oxygen; copper diacetate In 1-methyl-pyrrolidin-2-one at 120℃; under 760.051 Torr; for 20h;	93%
With ammonium acetate; oxygen; copper diacetate In 1-methyl-pyrrolidin-2-one at 120℃; under 760.051 Torr; for 20h;	93%

2'-chloro-benzeneacetic acid (2444-36-2) + isopropyl alcohol (67-63-0) → isopropyl 2-(2-chlorophenyl)-2-diazoacetate

Conditions	Yield
Stage #1: 2'-chloro-benzeneacetic acid; isopropyl alcohol With sulfuric acid at 90℃; for 12h; Stage #2: With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 12h;	92%

2'-chloro-benzeneacetic acid (2444-36-2) + di-tert-butyl-diazodicarboxylate (870-50-8) → di-tert-butyl 1-(2-chlorobenzyl)hydrazine-1,2-dicarboxylate

Conditions	Yield
With iron(III) sulfate; bis[(2-pyridyl)methyl]amine In 1,2-dichloro-ethane at 20℃; for 24h; Inert atmosphere; Sealed tube; Irradiation;	92%

2'-chloro-benzeneacetic acid (2444-36-2) → 2-Hydroxyphenylacetic acid (614-75-5)

Conditions	Yield
With copper(II) oxide; sodium hydroxide In water at 200℃; under 750.075 Torr; for 12h; Autoclave;	91.2%

Upstream product

• 623-11-0 1-methyl-4-nitrosobenzene 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 52900-69-3 4-(2-chlorobenzylidene)-2-phenyl-5-oxazolone 
• 178437-75-7 2-acetoxy-2-(2-chlorophenyl)acetic acid 
• 201230-82-2 carbon monoxide 
• 67013-54-1 o-chlorobenzal bromide 
• 124-38-9 carbon dioxide 
• 51801-46-8 (2-chloro-benzyl)-dimethyl-silane 
• 144616-14-8 ortho-chlorophenylmalonic acid 
• 119-64-2 tetralin 
• 7282-58-8 3-(2-chloro-phenyl)-2-thioxo-propionic acid 
• 98-85-1 1-Phenylethanol 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 

Downstream Products

• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 72776-18-2 1t,4t-bis-(2-chloro-phenyl)-buta-1,3-diene 
• 59-48-3 2-oxoindole 
• 98557-13-2 chloro-(2-chloro-phenyl)-acetyl chloride 
• 141055-19-8 (2-chloro-phenyl)-acetic acid-(4-nitro-benzyl ester) 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 3973-56-6 ((Ξ)-2-chloro-benzylidene)-phthalide 
• 6305-95-9 2-chlorophenylacetone 
• 728-04-1 trans-α-(2'-chlorophenyl)cinnamic acid 
• 23007-96-7 2-(o-chlorophenyl)2-hydroxymethylacetic acid 
• 100074-28-0 (2-Chloro-phenyl)-acetic acid ethoxycarbonylmethyl ester 
• 84966-80-3 2-(2-chlorophenyl)-N,N-dimethylacetamide 
• 27819-72-3 2'-chloro-3,4-dimethoxy-deoxybenzoin 
• 160749-00-8 methyl 2-chloro-α,α-dimethoxyphenylacetate 

Relevant articles and documents

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Method for converting benzyl borate compounds into phenylacetic acid and derivatives thereof by carbon dioxide

The invention discloses a method for converting benzyl borate compounds into phenylacetic acid and derivatives thereof by carbon dioxide. The method comprises the steps: dissolving the benzyl borate compounds and an alkali in an organic solvent in the absence of a metal catalyst, introducing carbon dioxide into the reaction system, carrying out a reaction at the temperature of 50-150 DEG C for 3-72 hours, and acidifying to obtain phenylacetic acid or the derivatives thereof. The method is a green, simple and efficient method for synthesizing phenylacetic acid and the derivatives thereof, greenhouse gas carbon dioxide is used as a carbon source in the reaction, no transition metal catalyst is used, and the method is environmentally friendly, economical and high in efficiency.

Preparation method of phenylacetic acid type compound

The invention discloses a preparation method of a phenylacetic acid type compound. The preparation method of the phenylacetic acid type compound I comprises the following steps that in a solvent and aCO gas phase system, a benzyl halide type compound II, pyridine-2-cobalt carboxylate, palladium acetate and alkaline neutralizers take carbonylation reaction to obtain the phenylacetic acid type compound I. A mixed catalytic system has a synergistic effect; the whole use quantity of catalysts is greatly reduced. When the mixed catalyst is used, a better catalytic effect can be achieved; the characteristics of easily obtaining the catalyst, avoiding the production safety risk of toxic three wastes and the like, reducing the reaction pressure, realizing mild reaction conditions, reducing the production risk, facilitating the production and the like are realized. The formulas are shown in description.