diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate

Base Information

• Chemical Name: diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate
• CAS No.: 368455-21-4
• Molecular Formula: C₂₂H₁₈O₄
• Molecular Weight: 346.383
• Mol file: 368455-21-4.mol

Synonyms:diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate

Chemical Property of diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate

There total 10 articles about diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethyl 5-[(4-[trimethysilylethynyl]phenyl)ethynyl]isophthaloate (368455-20-3) → diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate (368455-21-4)

Guidance literature:

With cesium fluoride; In tetrahydrofuran; ethanol;

DOI:10.1021/ja3055639

Reference yield:

diethyl 5-iodo-1,3-benzenedicarboxylate (368455-15-6) → diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate (368455-21-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / Pd(Ph₃P)4; piperidine; CuI / 3 h / 20 °C

2: 93 percent / Cs₂CO₃; EtOH / CH₂Cl₂ / 1 h / 20 °C

3: 88 percent / Pd(Ph₃P)4; piperidine; CuI / 3 h / 20 °C

4: 87 percent / Cs₂CO₃; EtOH / CH₂Cl₂ / 1 h / 20 °C

With piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; caesium carbonate; In dichloromethane;

DOI:10.1021/ja010019h

Reference yield:

diethyl 5-(trimethylsilylethynyl)isophthaloate (368455-17-8) → diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate (368455-21-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / Cs₂CO₃; EtOH / CH₂Cl₂ / 1 h / 20 °C

2: 88 percent / Pd(Ph₃P)4; piperidine; CuI / 3 h / 20 °C

3: 87 percent / Cs₂CO₃; EtOH / CH₂Cl₂ / 1 h / 20 °C

With piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; caesium carbonate; In dichloromethane;

DOI:10.1021/ja010019h

upstream raw materials:

diethyl 5-[(4-[trimethysilylethynyl]phenyl)ethynyl]isophthaloate

5-aminoisophthalic acid

diethyl 5-iodo-1,3-benzenedicarboxylate

diethyl 5-aminoisophthalate

Downstream raw materials:

diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate

hexaethyl 5,5',5''-(benzene-1,3,5-triyltris(ethyne-2,1-diylbenzene-4,1-diylethyne-2,1-diyl))triisophthalate

C₉₀H₆₆O₁₂

diethyl 5-[(4-[(4-ethynylphenyl)ethynyl]phenyl)ethynyl]isophthaloate