diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate

Base Information

Chemical Name:diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate
CAS No.:368455-23-6
Molecular Formula:C₃₃H₃₀O₄Si
Molecular Weight:518.684
Hs Code.:

Synonyms:diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate

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Chemical Property of diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate

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Technology Process of diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate

There total 11 articles about diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 134856-58-9
1-iodo-4-(trimethylsilylethynyl)benzene

: 368455-21-4
diethyl 5-[(4-ethynylphenyl)ethynyl]isophthaloate

: 368455-23-6
diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate

Guidance literature:: With piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 20 ℃; for 3h;
DOI:10.1021/ja010019h

Reference yield:

: 75867-39-9
4-trimethylsilylethynyl aniline

: 368455-23-6
diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaNO₂; aq. HCl / 0.75 h / 0 - 5 °C

1.2: 65 percent / KI / CH₂Cl₂; H₂O / 4 h / 20 °C

2.1: 88 percent / Pd(Ph₃P)4; piperidine; CuI / 3 h / 20 °C

3.1: 87 percent / Cs₂CO₃; EtOH / CH₂Cl₂ / 1 h / 20 °C

4.1: 96 percent / Pd(Ph₃P)4; piperidine; CuI / 3 h / 20 °C

With piperidine; hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; caesium carbonate; sodium nitrite; In dichloromethane;
DOI:10.1021/ja010019h

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 368455-23-6
diethyl 5-[(4-[(4-[trimethysilylethynyl]phenyl)ethynyl]phenyl)ethynyl]isophthaloate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / Pd(Ph₃P)4; piperidine; CuI / 3 h / 20 °C

2.1: NaNO₂; aq. HCl / 0.75 h / 0 - 5 °C

2.2: 65 percent / KI / CH₂Cl₂; H₂O / 4 h / 20 °C

3.1: 88 percent / Pd(Ph₃P)4; piperidine; CuI / 3 h / 20 °C

4.1: 87 percent / Cs₂CO₃; EtOH / CH₂Cl₂ / 1 h / 20 °C

5.1: 96 percent / Pd(Ph₃P)4; piperidine; CuI / 3 h / 20 °C

With piperidine; hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; caesium carbonate; sodium nitrite; In dichloromethane;
DOI:10.1021/ja010019h