(S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate

Base Information

Chemical Name:(S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate
CAS No.:356058-50-9
Molecular Formula:C₃₆H₄₃FO₇
Molecular Weight:606.732
Hs Code.:

Synonyms:(S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate

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Chemical Property of (S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate

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Technology Process of (S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate

There total 10 articles about (S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 106315-86-0
(S)-(+)-2-methylbutyl 4-hydroxy-2-fluorobenzoate

: 196864-81-0
4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylic acid

: 356058-50-9
(S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1039/b009426i

Reference yield:

: 372-20-3
3-fluorophenol

: 356058-50-9
(S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: Br₂; AcOH

2: 96 percent / K₂CO₃ / butan-2-one

3: 71 percent / 1-methyl-pyrrolidin-2-one / 24 h / Heating

4: 58 percent / aq. NaOH / 60 h / Heating

5: 93 percent / DEAD; PPh₃ / tetrahydrofuran

6: 78 percent / H₂ / 10 percent Pd/C / ethyl acetate

7: 62 percent / DCC; DMAP / CH₂Cl₂ / 72 h / 20 °C

With dmap; sodium hydroxide; hydrogen; bromine; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; ethyl acetate; butanone;
DOI:10.1039/b009426i

Reference yield:

: 121219-03-2
4-bromo-3-fluorophenol

: 356058-50-9
(S)-(+)-4-(2-methylbutyloxycarbonyl)-3-fluorophenyl 4'-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]biphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / K₂CO₃ / butan-2-one

2: 71 percent / 1-methyl-pyrrolidin-2-one / 24 h / Heating

3: 58 percent / aq. NaOH / 60 h / Heating

4: 93 percent / DEAD; PPh₃ / tetrahydrofuran

5: 78 percent / H₂ / 10 percent Pd/C / ethyl acetate

6: 62 percent / DCC; DMAP / CH₂Cl₂ / 72 h / 20 °C

With dmap; sodium hydroxide; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; ethyl acetate; butanone;
DOI:10.1039/b009426i