[2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine

Base Information

Chemical Name:[2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine
CAS No.:360577-04-4
Molecular Formula:C₂₂H₃₃N₃O₂
Molecular Weight:371.523
Hs Code.:

Synonyms:[2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine

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Chemical Property of [2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine

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Technology Process of [2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine

There total 6 articles about [2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 360576-57-4
[4-methoxy-2-(2-methoxy-4,6-dimethyl-phenyl)-6-methyl-pyrimidin-5-yl]-dipropylamine

: 74-88-4
methyl iodide

: 360577-04-4
[2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine

Guidance literature:: [4-methoxy-2-(2-methoxy-4,6-dimethyl-phenyl)-6-methyl-pyrimidin-5-yl]-dipropylamine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/S0960-894X(03)00483-9

Reference yield:

: 13162-26-0
2,4-dichloro-6-methyl-5-nitropyrimidine

: 360577-04-4
[2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 35 percent / methanol

2.1: 65 percent / [Pd(PPh₃)4]; NaHCO₃ / toluene / 70 °C

3.1: 100 percent / H₂ / Pd/C / atmospheric pressure

4.1: 100 percent / AcOH; NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

5.1: LDA / tetrahydrofuran / -78 °C

5.2: 75 percent / tetrahydrofuran / -78 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; toluene; 2.1: Suzuki coupling;
DOI:10.1016/S0960-894X(03)00483-9

Reference yield:

: 16632-21-6
6-methyl-5-nitropyrimidine-2,4-diol

: 360577-04-4
[2-(2-methoxy-4,6-dimethylphenyl)-4-methoxy-6-ethyl pyrimidin-5-yl]dipropylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 60 percent / POCl₃; PhNEt₂ / Heating

2.1: 35 percent / methanol

3.1: 65 percent / [Pd(PPh₃)4]; NaHCO₃ / toluene / 70 °C

4.1: 100 percent / H₂ / Pd/C / atmospheric pressure

5.1: 100 percent / AcOH; NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

6.1: LDA / tetrahydrofuran / -78 °C

6.2: 75 percent / tetrahydrofuran / -78 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; N,N-diethylaniline; lithium diisopropyl amide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; toluene; 3.1: Suzuki coupling;
DOI:10.1016/S0960-894X(03)00483-9