5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid

Base Information

• Chemical Name: 5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid
• CAS No.: 1013935-36-8
• Molecular Formula: C₂₇H₂₆N₂O₄
• Molecular Weight: 442.514

Synonyms:5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid

Chemical Property of 5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid

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Technology Process of 5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid

There total 3 articles about 5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 5-[1-(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate (1013935-34-6) → 5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid (1013935-36-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water; for 5h; Heating;

DOI:10.1134/S1070428007020236

Reference yield:

1-phenyl-2-nitroprop-1-ene (705-60-2,18315-84-9,58321-79-2) → 5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid (1013935-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / DBU / tetrahydrofuran; propan-2-ol / 3 h / 20 °C

2: 71 percent / methanesulfonic acid / CH₂Cl₂ / 24 h

3: 96 percent / NaOH / tetrahydrofuran; methanol; H₂O / 5 h / Heating

With sodium hydroxide; methanesulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol;

DOI:10.1134/S1070428007020236

Reference yield:

ethyl 4-methyl-3-phenyl-1H-pyrrole-2-carboxylate (124901-12-8) → 5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid (1013935-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / methanesulfonic acid / CH₂Cl₂ / 24 h

2: 96 percent / NaOH / tetrahydrofuran; methanol; H₂O / 5 h / Heating

With sodium hydroxide; methanesulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1134/S1070428007020236

upstream raw materials:

ethyl 5-[1-(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)-1-methylethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate

1-phenyl-2-nitroprop-1-ene

ethyl 4-methyl-3-phenyl-1H-pyrrole-2-carboxylate

Downstream raw materials:

C₂₇H₂₄Cl₂N₂O₂

5,5'-(propane-2,2-diyl)bis(N-(3-aminophenyl)-4-methyl-3-phenyl-1H-pyrrole-2-carboxamide)

C₃₉H₃₈N₆O₂

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