methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate

Base Information

Chemical Name:methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate
CAS No.:403607-28-3
Molecular Formula:C₃₄H₄₇Cl₂NO₅
Molecular Weight:620.657
Hs Code.:

Synonyms:methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate

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Chemical Property of methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate

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Technology Process of methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate

There total 5 articles about methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 2905-62-6
3,5-dichlorobenzoyl chloride

: 403607-29-4
methyl 3α-acetyloxy-12α-amino-5β-cholan-24-oate

: 403607-28-3
methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1016/S0957-4166(01)00490-6

Reference yield:

: 83-44-3
Deoxycholic acid

: 403607-28-3
methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 5 steps

1.1: p-toluenesulphonic acid / H₂O / Heating

2.1: 95 percent / K₂Cr₂O₇ / H₂O; acetic acid / 20 h / 20 °C

3.1: 94 percent / AcONa; NH₂OH*HCl / methanol / 4.5 h / Heating

4.1: H₂ / PtO₂ / acetic acid / 144 h / 20 °C

4.2: 90 percent / Zn; acetic acid / 12 h / 20 °C

5.1: 91 percent / Et₃N / tetrahydrofuran / 4 h / 20 °C

With potassium dichromate; hydroxylamine hydrochloride; hydrogen; sodium acetate; toluene-4-sulfonic acid; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1016/S0957-4166(01)00490-6

Reference yield:

: 27240-83-1
methyl 3α-acetoxy-12α-hydroxy-5β-cholan-24-oate

: 403607-28-3
methyl 3α-acetyloxy-12α-N-(3,5-dichlorobenzoyl)amino-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / K₂Cr₂O₇ / H₂O; acetic acid / 20 h / 20 °C

2.1: 94 percent / AcONa; NH₂OH*HCl / methanol / 4.5 h / Heating

3.1: H₂ / PtO₂ / acetic acid / 144 h / 20 °C

3.2: 90 percent / Zn; acetic acid / 12 h / 20 °C

4.1: 91 percent / Et₃N / tetrahydrofuran / 4 h / 20 °C

With potassium dichromate; hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1016/S0957-4166(01)00490-6