3,4-Dihydroxy-L-phenylalanine benzyl ester hydrochloride

Base Information

• Chemical Name: 3,4-Dihydroxy-L-phenylalanine benzyl ester hydrochloride
• CAS No.: 37178-28-2
• Molecular Formula: C16H18ClNO4
• Molecular Weight: 323.776
• Mol file: 37178-28-2.mol

Synonyms:3,4-Dihydroxy-L-phenylalanine benzyl ester hydrochloride;L-Dopa benzyl ester hydrochloride;ALANINE, 3-(3,4-DIHYDROXYPHENYL)-, BENZYL ESTER, HYDROCHLORIDE, L-;SCHEMBL4188588;L-Tyrosine, 3-hydroxy-, phenylmethyl ester, hydrochloride;LS-16065;[3-(3,4-dihydroxyphenyl)-1-oxo-1-phenylmethoxypropan-2-yl]azanium;chloride

Chemical Property of 3,4-Dihydroxy-L-phenylalanine benzyl ester hydrochloride

Chemical Property:

• Vapor Pressure: 5.33E-10mmHg at 25°C
• Boiling Point: 484.2°C at 760 mmHg
• Flash Point: 246.6°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 323.0924357
• Heavy Atom Count: 22
• Complexity: 330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)C(CC2=CC(=C(C=C2)O)O)[NH3+].[Cl-]

Technology Process of 3,4-Dihydroxy-L-phenylalanine benzyl ester hydrochloride

There total 3 articles about 3,4-Dihydroxy-L-phenylalanine benzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

levodopa (59-92-7,90638-38-3) + benzyl alcohol (100-51-6,185532-71-2) → L-3,4-dihydroxyphenylalanine benzyl ester hydrochloride (37178-28-2)

Guidance literature:

With toluene-4-sulfonic acid; at 80 ℃; for 2h;

DOI:10.1111/j.1751-1097.2007.00295.x

Reference yield: 32.0%

levodopa (59-92-7,90638-38-3) → benzyl ester hydrochloride + L-3,4-dihydroxyphenylalanine benzyl ester hydrochloride (37178-28-2)

Guidance literature:

With thionyl chloride; In benzyl alcohol;

Reference yield:

→ L-3,4-dihydroxyphenylalanine benzyl ester hydrochloride (37178-28-2)

Guidance literature:

upstream raw materials:

levodopa

benzyl alcohol

Downstream raw materials:

3,4-dihydroxyindole-2-carboxylic acid benzyl ester

6-Hydroxy-5-oxo-3,5-dihydro-2H-indole-2-carboxylic acid benzyl ester

C₃₁H₃₆N₂O₇

C₂₅H₃₂N₂O₇