4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Base Information

Chemical Name:4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt
CAS No.:1355488-61-7
Molecular Formula:C₄H₁₁N*C₁₄H₁₁ClF₂N₂O₄S
Molecular Weight:449.906
Hs Code.:

Synonyms:4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

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Chemical Property of 4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

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Technology Process of 4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

There total 5 articles about 4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864758-02-1
(5-chloro-2-pyridinyl)methyl methanesulfonate

: 1354963-02-2
2,5-difluoro-4-hydroxy-N-(methylsulfonyl)benzamide

: 109-89-7
diethylamine

: 1355488-61-7
4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Guidance literature:: (5-chloro-2-pyridinyl)methyl methanesulfonate; 2,5-difluoro-4-hydroxy-N-(methylsulfonyl)benzamide; With potassium carbonate; In dimethyl sulfoxide; at 50 ℃;

diethylamine; In acetonitrile;

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 1355488-61-7
4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide / 18 h / Inert atmosphere; Reflux

1.2: pH 2

2.1: dimethyl sulfoxide / 21 h / 20 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 3 h / 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 50 °C

With hydrogenchloride; water; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 209526-98-7
(5-chloro-2-pyridinyl)methanol

: 1355488-61-7
4-[(5-chloropyridin-2-yl)methoxy]-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 50 °C

With potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide;