2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Base Information

Chemical Name:2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
CAS No.:1356009-87-4
Molecular Formula:C₂₆H₂₅ClFN₇O₃
Molecular Weight:537.981
Hs Code.:

Synonyms:2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

There total 14 articles about 2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.2%

: 1263868-30-9
2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

: 1356009-28-3
N-methyl-3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propan-1-amine

: 1356009-87-4
2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 120-92-3
cyclopentanone

: 1356009-87-4
2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / 20 - 50 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / 100 °C

5: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; diethyl ether; acetonitrile;

Reference yield:

: 1009-36-5
2-chloro-5-nitroanisole

: 1356009-87-4
2-chloro-7-(4-fluorophenyl)-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: boron tribromide / dichloromethane / -78 - 4 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 18 h / 20 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 18 h / 95 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

6.2: 1 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

With boron tribromide; sodium hydride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;