(3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one

Base Information

• Chemical Name: (3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one
• CAS No.: 1061681-41-1
• Molecular Formula: C₂₆H₂₅NO₂
• Molecular Weight: 383.49
• Mol file: 1061681-41-1.mol

Synonyms:(3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one

Chemical Property of (3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one

There total 1 articles about (3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(3R,11aR)-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one (1061681-28-4) + benzyl bromide (100-39-0) → (3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one (1061681-41-1)

Guidance literature:

(3R,11aR)-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 0 ℃; for 2h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.05.017

Reference yield: 66.0%

(3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one (1061681-41-1) → C26H29NO (1061681-46-6)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/j.tetasy.2008.06.016

Reference yield: 66.0%

(3R,6S,11aR)-6-benzyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one (1061681-41-1) → (R)-2-[(1S,4S)-1-benzyl-4-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl]-2-phenylethanol

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.05.017

upstream raw materials:

(3R,11aR)-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

benzyl bromide

Downstream raw materials:

C₂₆H₂₉NO