1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol

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Chemical Name:1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol
CAS No.:949115-59-7
Molecular Formula:C₄₁H₅₁N₂O₇P
Molecular Weight:714.839
Hs Code.:

Synonyms:1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol

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Chemical Property of 1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol

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Technology Process of 1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol

There total 4 articles about 1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 949115-58-6
1-O-(4,4'-dimethoxytrityl)-2,2-bis(propargyloxymethyl)-1,3-propanediol

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 949115-59-7
1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol

Guidance literature:: 1-O-(4,4'-dimethoxytrityl)-2,2-bis(propargyloxymethyl)-1,3-propanediol; With N,N-diisopropylamine tetrazolide; In acetonitrile;

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 2425-41-4
5,5-dihydroxymethyl-2-phenyl-1,3-dioxane

: 949115-59-7
1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 0 - 40 °C

2.1: acetic acid / water / 2 h / 50 °C

3.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4.1: benzyl tetrazol-5-yl sulphide / dichloromethane; acetonitrile / 2 h / 20 °C / Inert atmosphere

With dmap; benzyl tetrazol-5-yl sulphide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile; mineral oil;

Reference yield:

: 2-phenyl-5,5-bis(prop-2-ynyloxymethyl)-1,3-dioxane

: 949115-59-7
1-O-(4,4'-dimethoxytrityloxymethyl)-2,2-bis-propargyloxymethyl-3-{O-[(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite]}-1,3-propanediol

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / water / 2 h / 50 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3: benzyl tetrazol-5-yl sulphide / dichloromethane; acetonitrile / 2 h / 20 °C / Inert atmosphere

With dmap; benzyl tetrazol-5-yl sulphide; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile;