tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate
CAS No.:1464154-63-9
Molecular Formula:C₃₂H₃₄N₆O₃
Molecular Weight:550.66
Hs Code.:

Synonyms:tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate

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Chemical Property of tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate

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Technology Process of tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate

There total 4 articles about tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 440101-15-5
tert-butyl (4-ethylpiperidin-4-yl)carbamate

: 1464154-43-5
4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 1464154-63-9
tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1082604-63-4
4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile

: 1464154-63-9
tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 90 °C

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; HATU; In water; N,N-dimethyl-formamide;

Reference yield:

: 923595-49-7
6-chloro-3-iodo-imidazo[1,2-b]pyridazine

: 1464154-63-9
tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-ethylpiperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 90 °C

3: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; HATU; In water; N,N-dimethyl-formamide;