6-Chloro-3-iodoimidazo[1,2-B]pyridazine

Base Information

• Chemical Name: 6-Chloro-3-iodoimidazo[1,2-B]pyridazine
• CAS No.: 923595-49-7
• Molecular Formula: C6H3ClIN3
• Molecular Weight: 279.467
• Hs Code.: 2933990090
• European Community (EC) Number: 851-079-0
• DSSTox Substance ID: DTXSID40693117
• Wikidata: Q72452458
• Mol file: 923595-49-7.mol

Synonyms:6-CHLORO-3-IODOIMIDAZO[1,2-B]PYRIDAZINE;923595-49-7;6-chloro-3-iodo-imidazo[1,2-b]pyridazine;6-Chloro-3-iodoimidazo[1,2-a]pyridazine;6-Chloro-3-iodoimidazo[1,2b]pyridazine;MFCD11044749;Imidazo[1,2-b]pyridazine, 6-chloro-3-iodo-;SCHEMBL2943467;DTXSID40693117;IWHCPHZAMFSDFM-UHFFFAOYSA-N;BCP07796;YLB59549;AKOS015950464;CS-W004254;SB15408;AM807810;SY110201;FT-0685958;EN300-215662;6-chloranyl-3-iodanyl-imidazo[1,2-b]pyridazine;A844208;J-518549;Z1269213261

Chemical Property of 6-Chloro-3-iodoimidazo[1,2-B]pyridazine

Chemical Property:

• PKA: 1.03±0.30(Predicted)
• PSA: 30.19000
• Density: 2.346 g/cm³
• LogP: 1.98730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 278.90602
• Heavy Atom Count: 11
• Complexity: 157

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-3-iodoimidazo[1,2-a]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NN2C1=NC=C2I)Cl

Technology Process of 6-Chloro-3-iodoimidazo[1,2-B]pyridazine

There total 2 articles about 6-Chloro-3-iodoimidazo[1,2-B]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → 6-chloro-3-iodo-imidazo[1,2-b]pyridazine (923595-49-7)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 23 ℃; for 48h; Inert atmosphere;

Reference yield: 84.0%

C13H24ClN3O2Si3 → 6-chloro-3-iodo-imidazo[1,2-b]pyridazine (923595-49-7)

Guidance literature:

With N-iodo-succinimide; silver fluoride; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere; Glovebox;

DOI:10.1021/ja511352u

Reference yield: 98.0%

6-chloro-3-iodo-imidazo[1,2-b]pyridazine (923595-49-7) + 4-cyanophenylboronic acid (126747-14-6) → 4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile (1082604-63-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 18h; Inert atmosphere;

upstream raw materials:

6-chloroimidazo[1,2-b]pyridazine

Downstream raw materials:

2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)benzofuran-3-carboxamide

6-chloro-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine

4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid

4-(6-(4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Refernces

• 1、 -. "AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY". Paragraph 0418; 0419. . Retrieved 2019/06/07.
• 2、 -. "Aromatic heterocyclic compound serving as PI3K/mTOR kinase regulator and preparation method and application of aromatic heterocyclic compound". Paragraph 0141; 0242. . Retrieved 2019/08/12.