7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile

Base Information

Chemical Name:7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile
CAS No.:1198747-13-5
Molecular Formula:C₂₁H₁₅F₃N₄O
Molecular Weight:396.372
Hs Code.:

Synonyms:7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile

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Chemical Property of 7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile

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Technology Process of 7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile

There total 2 articles about 7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 115859-76-2
2-(tetrahydropyrimidin-2(1H)-ylidene)-1-(p-tolyl)ethan-1-one

: 2377-81-3
tetrafluoroisophthalonitrile

: 1198747-13-5
7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile

Guidance literature:: 2-(tetrahydropyrimidin-2(1H)-ylidene)-1-(p-tolyl)ethan-1-one; tetrafluoroisophthalonitrile; at 120 ℃; for 0.2h; Microwave irradiation; Neat (no solvent);

With potassium tert-butylate; In 1,4-dioxane; at 20 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2011.01.036

Reference yield:

: C₂₁H₁₅F₃N₄O

: 1198747-13-5
7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile

Guidance literature:: With potassium tert-butylate; In 1,4-dioxane; at 20 ℃; for 0.5h; Combinatorial reaction / High throughput screening (HTS);
DOI:10.1021/cc900121c

Reference yield: 86.0%

: 1198747-13-5
7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile

: 1198747-27-1
C₂₁H₁₄F₃N₃O₂

Guidance literature:: 7,9,10-trifluoro-6-imino-11-(4-methylbenzoyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile; With hydrogenchloride; water; In ethanol; for 24h; Reflux; Combinatorial reaction / High throughput screening (HTS);

With sodium carbonate; In ethanol; water; at 20 ℃; pH=8 - 9; Combinatorial reaction / High throughput screening (HTS);
DOI:10.1021/cc900121c