(S)-N-(phenylacetyl)-α-phenylglycinonitrile

Base Information

• Chemical Name: (S)-N-(phenylacetyl)-α-phenylglycinonitrile
• CAS No.: 345643-03-0
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.3
• Mol file: 345643-03-0.mol

Synonyms:(S)-N-(phenylacetyl)-α-phenylglycinonitrile

Chemical Property of (S)-N-(phenylacetyl)-α-phenylglycinonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(phenylacetyl)-α-phenylglycinonitrile

There total 3 articles about (S)-N-(phenylacetyl)-α-phenylglycinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phenylacetic acid (103-82-2) + 2-phenylglycinonitrile hydrochloride (53641-60-4,53941-45-0) → (S)-N-(phenylacetyl)-α-phenylglycinonitrile (345643-03-0) + (R)-α-phenylglycinonitrile hydrochloride (53941-45-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; E_. coli penicillin acylase; In water; at 5 ℃; pH=5.0;

DOI:10.1016/S0957-4166(03)00523-8

Reference yield: 47.0%

Ethyl 2-phenylethanoate (101-97-3) + 2-amino-2-phenylacetonitrile (16750-42-8,41804-94-8) → (S)-N-(phenylacetyl)-α-phenylglycinonitrile (345643-03-0)

Guidance literature:

With Novozym 435; Zeolite NaA; In di-isopropyl ether; at 40 ℃; for 24h;

DOI:10.1016/S0957-4166(01)00011-8

Reference yield:

phenylacetic acid (103-82-2) + 2-phenylglycinonitrile hydrochloride (53641-60-4,53941-45-0) → (S)-N-(phenylacetyl)-α-phenylglycinonitrile (345643-03-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; E_. coli penicillin acylase; In water; at 5 ℃; pH=5; Equilibrium constant;

DOI:10.1016/S0957-4166(03)00523-8

upstream raw materials:

Ethyl 2-phenylethanoate

2-amino-2-phenylacetonitrile

phenylacetic acid

2-phenylglycinonitrile hydrochloride

Downstream raw materials:

phenylacetic acid

(S)-α-phenylglycinenitrile