Aminophenylacetonitrile

Base Information

• Chemical Name: Aminophenylacetonitrile
• CAS No.: 16750-42-8
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.165
• Hs Code.: 2926909090
• Mol file: 16750-42-8.mol

Synonyms:Acetonitrile,aminophenyl- (6CI,8CI); (?à)-Phenylglycinonitrile; 2-Amino-2-phenylacetonitrile;2-Phenylglycinonitrile; DL-Aminophenylacetonitrile; NSC 118098; a-Amino-a-phenylacetonitrile; a-Aminobenzyl cyanide; a-Aminophenylacetonitrile; a-Cyanobenzylamine

Chemical Property of Aminophenylacetonitrile

Chemical Property:

• Melting Point: 55 °C
• Boiling Point: 235.8°Cat760mmHg
• PKA: 5.03±0.10(Predicted)
• Flash Point: 96.4°C
• PSA: 49.81000
• Density: 1.1g/cm³
• LogP: 1.91028

Purity/Quality:

98%min ^*data from raw suppliers

2-amino-2-phenylacetonitrile 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Aminophenylacetonitrile

There total 32 articles about Aminophenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

potassium cyanide (151-50-8) + benzaldehyde (100-52-7) → 2-amino-2-phenylacetonitrile (16750-42-8,41804-94-8)

Guidance literature:

With aluminum oxide; ammonium chloride; In acetonitrile; at 50 ℃; for 24h; ultrasonic irradiation;

DOI:10.1246/cl.1987.687

Reference yield: 90.0%

trimethylsilyl cyanide (7677-24-9) + benzylamine (100-46-9) → 2-amino-2-phenylacetonitrile (16750-42-8,41804-94-8)

Guidance literature:

With 5,10,15,20-tetraphenyl-21H,23H-porphine; tetrabutyl ammonium fluoride; oxygen; In tetrahydrofuran; at -50 ℃; for 0.05h; under 11251.1 Torr; Irradiation;

DOI:10.1002/anie.201307778

Reference yield: 89.0%

(RS)-mandelonitrile (532-28-5,613-88-7) → 2-amino-2-phenylacetonitrile (16750-42-8,41804-94-8)

Guidance literature:

With titanium(IV) isopropylate; ammonia; In methanol; at 40 ℃; for 18h;

DOI:10.1021/acs.orglett.9b03194

upstream raw materials:

benzylidenamine

ammonium cyanide

(RS)-mandelonitrile

hydrogen cyanide

Downstream raw materials:

2,2-dimethyl-4-phenyl-oxazolidin-5-one-imine

2,2-dimethyl-5-phenyl-imidazolidine-4-thione

amino-phenyl-thioacetic acid amide

1-phenyl-1-acetylamino-2-acetylaminoethane

Refernces

• 1、 -. "NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1". Page/Page column 96. . Retrieved 2020/12/11.
• 2、 Basha, Mushkin,Belema, Makonen,Dhar, T. G. Murali,Gupta, Anuradha,Gupta, Arun Kumar,Indasi, Gopi Kumar,Karmakar, Ananta,Mathur, Arvind,Meanwell, Nicholas A.,Ramalingam, Sridharan,Rampulla, Richard. "Facile Access to 1,4-Disubstituted Pyrrolo[1,2- a ]pyrazines from α-Aminoacetonitriles". supporting information. p. 441 - 449. Retrieved 2020/01/23.