4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester

Base Information

• Chemical Name: 4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester
• CAS No.: 134403-93-3
• Molecular Formula: C₄₂H₄₁N₃O₁₃
• Molecular Weight: 795.8
• Mol file: 134403-93-3.mol

Synonyms:4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester

Chemical Property of 4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester

There total 1 articles about 4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-(methoxycarbonyl)-2-nitrophenyl)ethyl chloroformate (134403-97-7) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester (134403-93-3)

Guidance literature:

With dmap; In dichloromethane; Product distribution; various bases;

DOI:10.1016/S0040-4020(01)92195-7

Reference yield: 60.0%

4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester (134403-93-3) → 4-{2-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxycarbonyloxy]-ethyl}-3-nitro-benzoic acid (134403-94-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; acetonitrile; for 0.0833333h; Ambient temperature;

DOI:10.1016/S0040-4020(01)92195-7

upstream raw materials:

2-(4-(methoxycarbonyl)-2-nitrophenyl)ethyl chloroformate

5'-O-(4-4'-dimethoxytrityl)thymidine

Downstream raw materials:

4-{2-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxycarbonyloxy]-ethyl}-3-nitro-benzoic acid