Technology Process of 4-hydroxy-4-methyl-2-phenylpent-1-en-3-one
There total 3 articles about 4-hydroxy-4-methyl-2-phenylpent-1-en-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(2-phenylcycloprop-1-enyl)propan-2-ol;
With
titanium(IV)isopropoxide;
In
dichloromethane;
at -20 ℃;
for 0.5h;
Molecular sieve;
With
tert.-butylhydroperoxide;
In
dichloromethane;
at -20 ℃;
Molecular sieve;
DOI:10.1021/ol201581c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: cetyltrimethylammonim bromide; sodium hydroxide / dichloromethane; water
2.1: n-butyllithium / diethyl ether; hexane / -80 - -40 °C
2.2: 2 h / -40 - -20 °C
3.1: titanium(IV)isopropoxide / dichloromethane / 0.5 h / -20 °C / Molecular sieve
3.2: -20 °C / Molecular sieve
With
n-butyllithium; cetyltrimethylammonim bromide; titanium(IV)isopropoxide; sodium hydroxide;
In
diethyl ether; hexane; dichloromethane; water;
3.1: Sharpless epoxidation / 3.2: Sharpless epoxidation;
DOI:10.1021/ol201581c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / diethyl ether; hexane / -80 - -40 °C
1.2: 2 h / -40 - -20 °C
2.1: titanium(IV)isopropoxide / dichloromethane / 0.5 h / -20 °C / Molecular sieve
2.2: -20 °C / Molecular sieve
With
n-butyllithium; titanium(IV)isopropoxide;
In
diethyl ether; hexane; dichloromethane;
2.1: Sharpless epoxidation / 2.2: Sharpless epoxidation;
DOI:10.1021/ol201581c
