4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide

Base Information

Chemical Name:4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide
CAS No.:181696-15-1
Molecular Formula:C₁₇H₁₃F₃N₂O₄S
Molecular Weight:398.362
Hs Code.:

Synonyms:4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide

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Chemical Property of 4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide

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Technology Process of 4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide

There total 6 articles about 4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: bis(1,2-chlorodimethylsilyl)ethane

: 1-(3-fluoro-4-methoxyphenyl)-2-(4-aminosulfonylphenyl-ethan-1-one oxime

: 219679-74-0
3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole

: 454-31-9
ethyl difluoroacetate

: 181696-15-1
4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide

Guidance literature:: With triethylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; water; ethyl acetate;

Reference yield: 13.0%

: C₁₇H₁₅F₃N₂O₅S

: 181696-15-1
4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; n-heptane; ethylbenzene; water; for 20h; Heating / reflux;

Reference yield:

: 4-[2-(3-fluoro-4-methoxy-phenyl)-2-oxo-ethyl]-benzenesulfonyl chloride

: 181696-15-1
4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / dichloromethane; water / 16 h

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 2 h / 75 °C / Heating / reflux

3.1: 1,2-bis-(chlorodimethylsilyl)ethane; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

3.2: -78 °C

3.3: 0.5 h / -15 °C

4.1: trifluoroacetic acid / tetrahydrofuran; n-heptane; ethylbenzene; water / 20 h / Heating / reflux

With 1,2-bis-(chlorodimethylsilyl)ethane; hydroxylamine hydrochloride; ammonia; sodium acetate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; ethylbenzene; water;