(S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester

Base Information

• Chemical Name: (S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester
• CAS No.: 1381810-54-3
• Molecular Formula: C₂₉H₄₈N₄O₅Si
• Molecular Weight: 560.809

Synonyms:(S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester

Chemical Property of (S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester

There total 4 articles about (S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester (1381810-40-7) → (S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester (1381810-54-3)

Guidance literature:

(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 1.5h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid (1381810-27-0) → (S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester (1381810-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / toluene / 0.5 h / 20 °C / Inert atmosphere

2: dmap / toluene / 20 °C

3: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.5 h / 0 °C

With dmap; trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane; toluene;

Reference yield:

C37H51Cl3N4O8Si → (S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester (1381810-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / toluene / 20 °C

2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.5 h / 0 °C

With dmap; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; toluene;

upstream raw materials:

(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid

(tert-butoxycarbonyl)-L-valine-L-(tert-butyldimethylsilyl)-meta-tyrosine-hexahydropyridazine-3S-carboxylic acid 2,2,2-trichloroethyl ester

(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

Downstream raw materials:

(E)-(8S,14S,17S,20R,21S)-21-hydroxy-14-(3-hydroxy-benzyl)-17-isopropyl-20-methyl-6-oxa-12,15,18,27-tetraaza-tricyclo[20.2.2.1*8,12*]heptacosa-1⁽²⁵⁾,2,22⁽²⁶⁾,23-tetraene-7,13,16,19-tetraone

(E)-(8S,14S,17S,20R,21S)-21-(t-butyl-dimethyl-silanyloxy)-14-[3-(t-butyl-dimethyl-silanyloxy)-benzyl]-17-isopropyl-20-methyl-6-oxa-12,15,18,27-tetraaza-tricyclo[20.2.2.1*8,12*]heptacosa-1⁽²⁵⁾,2,22⁽²⁶⁾,23-tetraene-7,13,16,19-tetraone

(8S,14S,17S,20R,21S)-21-hydroxy-14-(3-hydroxy-benzyl)-17-isopropyl-20-methyl-6-oxa-12,15,18,27-tetraaza-tricyclo[20.2.2.1*8,12*]heptacosa-1⁽²⁵⁾,22⁽²⁶⁾,23-triene-7,13,16,19-tetraone

(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

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