(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

Base Information

Chemical Name:(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester
CAS No.:1381810-47-4
Molecular Formula:C₄₂H₆₈N₄O₈Si
Molecular Weight:785.109
Hs Code.:

(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

Synonyms:(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

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Chemical Property of (S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

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Technology Process of (S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

There total 12 articles about (S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381810-62-3
(E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoic acid

: 1381810-54-3
(S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester

: 1381810-47-4
(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

Guidance literature:: (E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.666667h;

(S)-1-{(S)-2-((S)-2-amino-3-methyl-butyrylamino)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionyl}-hexahydro-pyridazine-3-carboxylic acid but-3-enyl ester; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1381811-00-2
2,2-dimethylpropionic acid (2S,3S,4R,5R)-3,5-dimethoxy-2,4-dimethyl-6-oxohexyl ester

: 1381810-47-4
(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium methylate; methanol / 20 °C / Inert atmosphere

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 0 °C

5.2: 20 °C

With methanol; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; sodium methylate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1381810-27-0
(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid

: 1381810-47-4
(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / toluene / 0.5 h / 20 °C / Inert atmosphere

2.1: dmap / toluene / 20 °C

3.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.5 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 0 °C

4.2: 20 °C

With dmap; trimethylsilyl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; toluene;