3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide

Base Information

• Chemical Name: 3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide
• CAS No.: 1605288-68-3
• Molecular Formula: C₁₃H₁₇ClN₂O₄S
• Molecular Weight: 332.808
• Mol file: 1605288-68-3.mol

Synonyms:3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide

Chemical Property of 3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide

There total 1 articles about 3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-aminoethyl)tetrahydrothiophene 1,1-dioxide (790594-67-1) + 2-chloro-3-nitrobenzaldehyde (58755-57-0) → 3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide (1605288-68-3)

Guidance literature:

3-(2-aminoethyl)tetrahydrothiophene 1,1-dioxide; 2-chloro-3-nitrobenzaldehyde; With magnesium sulfate; In dichloromethane; at 20 ℃;

With sodium tetrahydroborate; In dichloromethane; for 16h;

Reference yield: 33.0%

3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (129768-28-1) + 3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide (1605288-68-3) → N-(2-chloro-3-nitrobenzyl)-N-(2-(1,1-dioxidotetrahydrothiophen-3-yl)ethyl)-3(trifluoromethyl)-1H-pyrazole-5-carboxamide (1605285-64-0)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; acetonitrile; at 20 ℃; for 24h;

Reference yield:

3-(2-((2-chloro-3-nitrobenzyl)amino)ethyl)tetrahydrothiophene 1,1-dioxide (1605288-68-3) → C18H20ClF3N4O3S (1605285-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / acetonitrile; ethyl acetate / 24 h / 20 °C

2: hydrogen; nickel / ethanol / 50 °C / 2585.81 Torr

With hydrogen; nickel; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethanol; ethyl acetate; acetonitrile;

upstream raw materials:

3-(2-aminoethyl)tetrahydrothiophene 1,1-dioxide

2-chloro-3-nitrobenzaldehyde

Downstream raw materials:

N-(2-chloro-3-nitrobenzyl)-N-(2-(1,1-dioxidotetrahydrothiophen-3-yl)ethyl)-3(trifluoromethyl)-1H-pyrazole-5-carboxamide

C₁₈H₂₀ClF₃N₄O₃S