(S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane

Base Information

Chemical Name:(S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane
CAS No.:914675-55-1
Molecular Formula:C₄₉H₅₅N₂O₆P
Molecular Weight:798.959
Hs Code.:

Synonyms:(S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane

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Chemical Property of (S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane

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Technology Process of (S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane

There total 4 articles about (S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 914675-54-0
(S)-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butan-2-ol

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 914675-55-1
(S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane

Guidance literature:: With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/ejoc.200600168

Reference yield:

: (S)-4-(4-Phenylethynyl-benzyloxy)-butane-1,2-diol

: 914675-55-1
(S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane

Guidance literature:: Multi-step reaction with 2 steps

1: 230 mg / Et₃N / CH₂Cl₂ / 20 °C

2: 90 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 24 h / 20 °C

With N,N-diisopropylamine tetrazolide; triethylamine; In dichloromethane;
DOI:10.1002/ejoc.200600168

Reference yield:

: 914675-29-9
(S)-2,2-dimethyl-4-[2-(4-phenylethynylbenzyloxy)ethyl]-1,3-dioxolane

: 914675-55-1
(S)-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyloxy]-1-(4,4'-dimethoxytrityloxy)-4-[4-(phenylethynyl)phenylmethoxy]butane

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; H₂O / 24 h / 20 °C

2: 230 mg / Et₃N / CH₂Cl₂ / 20 °C

3: 90 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 24 h / 20 °C

With N,N-diisopropylamine tetrazolide; triethylamine; In dichloromethane; water; acetic acid;
DOI:10.1002/ejoc.200600168