propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester

Base Information

Chemical Name:propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester
CAS No.:266684-41-7
Molecular Formula:C₂₈H₃₅N₅O₅Si
Molecular Weight:549.702
Hs Code.:

propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-propyl ester

Synonyms:propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester

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Technology Process of propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester

There total 1 articles about propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 194159-18-7
ganciclovir monopropionate

: 266684-41-7
propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(99)02280-7

Reference yield: 85.0%

: 266684-41-7
propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester

: 266684-42-8
2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 0.266667h;
DOI:10.1016/S0040-4039(99)02280-7

Reference yield:

: 266684-41-7
propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester

: 266684-43-9
Isobutyric acid 3-(tert-butyl-diphenyl-silanyloxy)-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaOMe / methanol / 0.27 h / 20 °C

2: DMAP; pyridine / 1 h / Heating

With pyridine; dmap; sodium methylate; In methanol; 1: Hydrolysis / 2: Acylation;
DOI:10.1016/S0040-4039(99)02280-7