2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol

Base Information

Chemical Name:2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol
CAS No.:1443151-80-1
Molecular Formula:C₂₂H₂₄F₂N₄O₃
Molecular Weight:430.454
Hs Code.:

Synonyms:2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol

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Chemical Property of 2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol

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Technology Process of 2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol

There total 10 articles about 2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443152-04-2
tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

: 1443151-80-1
2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 1443151-66-3
2-[5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)-2-methoxyphenyl]propan-2-ol

: 1443151-80-1
2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sodium methylate / 240 h / Reflux

2.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 1 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With methanol; sodium methylate; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1443152-02-0
4-{[2-(4-fluorophenyl)ethyl]amino}-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-ol

: 1443151-80-1
2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

2.2: 1 h / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;