Technology Process of tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate
There total 8 articles about tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C
2.2: 1 h / 80 °C
With
sodium hydride; caesium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanol; sodium methylate / 240 h / Reflux
2.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C
3.2: 1 h / 80 °C
With
methanol; sodium methylate; sodium hydride; caesium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / 4.5 h / Reflux
2.1: magnesium / diethyl ether / Reflux
2.2: 2 h / Reflux
3.1: potassium acetate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere
4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / dichloromethane; water; 1,2-dimethoxyethane / 3 h / Reflux; Inert atmosphere
5.1: methanol; sodium methylate / 240 h / Reflux
6.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C
7.2: 1 h / 80 °C
With
methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); sulfuric acid; sodium methylate; potassium acetate; sodium hydride; caesium carbonate; magnesium;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;