tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

Base Information

Chemical Name:tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate
CAS No.:1443152-04-2
Molecular Formula:C₂₇H₃₂F₂N₄O₅
Molecular Weight:530.572
Hs Code.:

Synonyms:tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

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Chemical Property of tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

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Technology Process of tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

There total 8 articles about tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443152-02-0
4-{[2-(4-fluorophenyl)ethyl]amino}-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-ol

: 1443152-04-2
tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

2.2: 1 h / 80 °C

With sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1443151-66-3
2-[5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)-2-methoxyphenyl]propan-2-ol

: 1443152-04-2
tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol; sodium methylate / 240 h / Reflux

2.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 1 h / 80 °C

With methanol; sodium methylate; sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 2476-35-9
5-bromo-2-methoxybenzoic acid

: 1443152-04-2
tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 4.5 h / Reflux

2.1: magnesium / diethyl ether / Reflux

2.2: 2 h / Reflux

3.1: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / dichloromethane; water; 1,2-dimethoxyethane / 3 h / Reflux; Inert atmosphere

5.1: methanol; sodium methylate / 240 h / Reflux

6.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

7.2: 1 h / 80 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sodium methylate; potassium acetate; sodium hydride; caesium carbonate; magnesium; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;