tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

Base Information

• Chemical Name: tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate
• CAS No.: 1443152-04-2
• Molecular Formula: C₂₇H₃₂F₂N₄O₅
• Molecular Weight: 530.572
• Mol file: 1443152-04-2.mol

Synonyms:tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

Chemical Property of tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate

There total 8 articles about tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{[2-(4-fluorophenyl)ethyl]amino}-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-ol (1443152-02-0) → tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate (1443152-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

2.2: 1 h / 80 °C

With sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-[5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)-2-methoxyphenyl]propan-2-ol (1443151-66-3) → tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate (1443152-04-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol; sodium methylate / 240 h / Reflux

2.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 1 h / 80 °C

With methanol; sodium methylate; sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

5-bromo-2-methoxybenzoic acid (2476-35-9) → tert-butyl {4-(Fluoromethoxy)-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}[2-(4-fluorophenyl)ethyl]carbamate (1443152-04-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sulfuric acid / 4.5 h / Reflux

2.1: magnesium / diethyl ether / Reflux

2.2: 2 h / Reflux

3.1: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / dichloromethane; water; 1,2-dimethoxyethane / 3 h / Reflux; Inert atmosphere

5.1: methanol; sodium methylate / 240 h / Reflux

6.1: caesium carbonate / tetrahydrofuran / 48 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

7.2: 1 h / 80 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sodium methylate; potassium acetate; sodium hydride; caesium carbonate; magnesium; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2-[5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)-2-methoxyphenyl]propan-2-ol

4-{[2-(4-fluorophenyl)ethyl]amino}-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-ol

4-fluoro-2-phenethylamine

5-bromo-2-methoxybenzoic acid

Downstream raw materials:

2-{5-[4-(Fluoromethoxy)-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-yl]-2-methoxyphenyl}propan-2-ol

Refernces