1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol

Base Information

Chemical Name:1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol
CAS No.:1426149-84-9
Molecular Formula:C₁₇H₃₀O₄
Molecular Weight:298.423
Hs Code.:

Synonyms:1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol

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Chemical Property of 1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol

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Technology Process of 1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol

There total 6 articles about 1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426149-83-8
1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol

: 1426149-84-9
1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.01.087

Reference yield:

: 1426149-80-5
2,2’-(1,3-dioxane-2,2-diyl)diethanol

: 1426149-84-9
1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; iodine; 1H-imidazole / benzene; diethyl ether / 12 h / 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; mineral oil; pentane; benzene;
DOI:10.1016/j.tetlet.2013.01.087

Reference yield:

: 1426149-81-6
2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethanol

: 1426149-84-9
1-{2-[2-(2-hydroxyethyl)-[1,3]-dioxan-2-yl]ethyl}-2,6,6-trimethylcyclohex-2-enol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; iodine; 1H-imidazole / benzene; diethyl ether / 12 h / 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; triphenylphosphine; In tetrahydrofuran; diethyl ether; pentane; benzene;
DOI:10.1016/j.tetlet.2013.01.087