1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol

Base Information

Chemical Name:1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol
CAS No.:1426149-83-8
Molecular Formula:C₂₃H₄₄O₄Si
Molecular Weight:412.685
Hs Code.:

Synonyms:1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol

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Chemical Property of 1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol

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Technology Process of 1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol

There total 5 articles about 1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 20013-73-4
2,6,6-trimethylcyclohex-2-en-1-one

: 1426149-82-7
tert-butyl-{2-[2-(2-iodoethyl)-[1,3]-dioxan-2-yl]ethoxy}dimethylsilane

: 1426149-83-8
1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol

Guidance literature:: tert-butyl-{2-[2-(2-iodoethyl)-[1,3]-dioxan-2-yl]ethoxy}dimethylsilane; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 1h; Inert atmosphere;

2,6,6-trimethylcyclohex-2-en-1-one; In diethyl ether; pentane; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.01.087

Reference yield:

: 1312466-15-1
diethyl 2,2’-(1,3-dioxane-2,2-diyl)diacetate

: 1426149-83-8
1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 0 - 20 °C / Inert atmosphere

3.1: triphenylphosphine; iodine; 1H-imidazole / benzene; diethyl ether / 12 h / 20 °C / Inert atmosphere

4.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere

4.2: 0.5 h / -78 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; iodine; tert.-butyl lithium; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; mineral oil; pentane; benzene;
DOI:10.1016/j.tetlet.2013.01.087

Reference yield:

: 1426149-80-5
2,2’-(1,3-dioxane-2,2-diyl)diethanol

: 1426149-83-8
1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; iodine; 1H-imidazole / benzene; diethyl ether / 12 h / 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

With 1H-imidazole; iodine; tert.-butyl lithium; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; mineral oil; pentane; benzene;
DOI:10.1016/j.tetlet.2013.01.087