Technology Process of 1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol
There total 5 articles about 1-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-[1,3]-dioxan-2-yl}ethyl)-2,6,6-trimethylcyclohex-2-enol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl-{2-[2-(2-iodoethyl)-[1,3]-dioxan-2-yl]ethoxy}dimethylsilane;
With
tert.-butyl lithium;
In
diethyl ether; pentane;
at -78 ℃;
for 1h;
Inert atmosphere;
2,6,6-trimethylcyclohex-2-en-1-one;
In
diethyl ether; pentane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2013.01.087
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 1 h / 0 - 20 °C / Inert atmosphere
3.1: triphenylphosphine; iodine; 1H-imidazole / benzene; diethyl ether / 12 h / 20 °C / Inert atmosphere
4.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere
4.2: 0.5 h / -78 °C / Inert atmosphere
With
1H-imidazole; lithium aluminium tetrahydride; iodine; tert.-butyl lithium; sodium hydride; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; mineral oil; pentane; benzene;
DOI:10.1016/j.tetlet.2013.01.087
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
1.2: 1 h / 0 - 20 °C / Inert atmosphere
2.1: triphenylphosphine; iodine; 1H-imidazole / benzene; diethyl ether / 12 h / 20 °C / Inert atmosphere
3.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere
3.2: 0.5 h / -78 °C / Inert atmosphere
With
1H-imidazole; iodine; tert.-butyl lithium; sodium hydride; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; mineral oil; pentane; benzene;
DOI:10.1016/j.tetlet.2013.01.087
