2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI

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Chemical Name:2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI
CAS No.:1299312-84-7
Molecular Formula:C₁₈H₁₁F₃N₄O
Molecular Weight:356.307
Hs Code.:

Synonyms:2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI

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Chemical Property of 2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI

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Technology Process of 2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI

There total 7 articles about 2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1299312-83-6
2-amino-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}-5-[2-(trimethylsilyl)ethynyl]indol-3-ol

: 1299312-84-7
2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

Reference yield:

: 5326-47-6
2-amino-5-iodobenzoic acid

: 1299312-84-7
2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere; Darkness

2.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 16 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 2 h / -80 °C / Inert atmosphere; Cooling with ether-dry ice

4.1: manganese(IV) oxide / diethyl ether / 30 h / 20 °C

5.1: dichloromethane / 0.67 h / 0 - 20 °C

6.1: ethanol; water / 16 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

With 4-methyl-morpholine; manganese(IV) oxide; n-butyllithium; tetrabutyl ammonium fluoride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; hexanes; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1299312-78-9
2-amino-N-methoxy-N-methyl-5-[2-(trimethylsilyl)ethynyl]benzamide

: 1299312-84-7
2-amino-5-ethynyl-3-{4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}indol-3-oI

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / tetrahydrofuran; hexanes / 2 h / -80 °C / Inert atmosphere; Cooling with ether-dry ice

2: manganese(IV) oxide / diethyl ether / 30 h / 20 °C

3: dichloromethane / 0.67 h / 0 - 20 °C

4: ethanol; water / 16 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

With manganese(IV) oxide; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexanes; diethyl ether; ethanol; dichloromethane; water;