2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid

Base Information

Chemical Name:2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid
CAS No.:1377565-77-9
Molecular Formula:C₂₆H₃₁NO₃S
Molecular Weight:437.603
Hs Code.:

Synonyms:2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid

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Chemical Property of 2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid

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Technology Process of 2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid

There total 3 articles about 2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.7%

: 1377567-50-4
ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate

: 1377565-77-9
2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid

Guidance literature:: ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate; With methanol; ethanol; sodium hydroxide; at 90 ℃; for 7h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 247206-89-9
LUF₅₅₂₇

: 1377565-77-9
2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 24 h / 100 °C / Inert atmosphere

1.2: pH 1

1.3: 21 h / Reflux

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / -10 - 20 °C

3.1: sodium hydroxide; ethanol; methanol / 7 h / 90 °C

3.2: pH 2

With methanol; ethanol; sodium ethanolate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1377567-49-1
ethyl [2-hydroxy-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]acetate

: 1377565-77-9
2-[2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / -10 - 20 °C

2.1: sodium hydroxide; ethanol; methanol / 7 h / 90 °C

2.2: pH 2

With methanol; ethanol; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;