ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate

Base Information

Chemical Name:ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate
CAS No.:1377567-50-4
Molecular Formula:C₂₈H₃₅NO₃S
Molecular Weight:465.657
Hs Code.:

Synonyms:ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate

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Chemical Property of ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate

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Technology Process of ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate

There total 4 articles about ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1377567-49-1
ethyl [2-hydroxy-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]acetate

: 107-08-4
1-iodo-propane

: 1377567-50-4
ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -10 - 20 ℃; for 18h;

Reference yield:

: 123-25-1
succinic acid diethyl ester

: 1377567-50-4
ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / ethanol / 24 h / 100 °C / Inert atmosphere

1.2: pH 1

1.3: 21 h / Reflux

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / -10 - 20 °C

With sodium ethanolate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 247206-89-9
LUF₅₅₂₇

: 1377567-50-4
ethyl [2-oxo-1-propyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / ethanol / 24 h / 100 °C / Inert atmosphere

1.2: pH 1

1.3: 21 h / Reflux

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / -10 - 20 °C

With sodium ethanolate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;